Technology Process of methyl (3α,5α,7α)-3-hydroxy-7-methoxymethyloxy-cholan-24-oate
There total 1 articles about methyl (3α,5α,7α)-3-hydroxy-7-methoxymethyloxy-cholan-24-oate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: phosphorus pentoxide / chloroform / 4 h / 20 °C / Inert atmosphere
2: 2-iodoxybenzoic acid / dimethyl sulfoxide / 72 h / 40 °C / Inert atmosphere
3: ammonia; lithium; tert-butyl alcohol / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere
4: potassium tri-sec-butyl-borohydride / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
With
2-iodoxybenzoic acid; phosphorus pentoxide; ammonia; lithium; potassium tri-sec-butyl-borohydride; tert-butyl alcohol;
In
tetrahydrofuran; chloroform; dimethyl sulfoxide;
3: Birch reduction;
DOI:10.1016/j.tetlet.2011.05.140