Pyrimidine, 2-[4-(bromomethyl)phenyl]- (9CI)

Base Information

• Chemical Name: Pyrimidine, 2-[4-(bromomethyl)phenyl]- (9CI)
• CAS No.: 77232-37-2
• Molecular Formula: C11H9 Br N2
• Molecular Weight: 249.10656
• Hs Code.: 2933599090
• Mol file: 77232-37-2.mol

Synonyms:Pyrimidine, 2-[4-(bromomethyl)phenyl]- (9CI)

Chemical Property of Pyrimidine, 2-[4-(bromomethyl)phenyl]- (9CI)

Chemical Property:

• PSA: 25.78000
• LogP: 3.03850

Purity/Quality:

2-(4-BROMOMETHYL-PHENYL)PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrimidine, 2-[4-(bromomethyl)phenyl]- (9CI)

There total 4 articles about Pyrimidine, 2-[4-(bromomethyl)phenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.6%

2-p-tolyl-pyrimidine (77232-13-4) → 2-(4-Bromomethyl-phenyl)-pyrimidine (77232-37-2)

Guidance literature:

With N-Bromosuccinimide; azobisisobutyronitrile; dibenzoyl peroxide; In tetrachloromethane; for 3h; Heating; Irradiation;

DOI:10.1002/hlca.19810640114

Reference yield:

p-methylbenzamidine hydrochloride (6326-27-8) → 2-(4-Bromomethyl-phenyl)-pyrimidine (77232-37-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 89.6 percent / sodium methylate / ethanol; methanol / 5 h / Heating

2: 89.2 percent / phosphorus oxychloride, N,N-dimethylaniline / 1 h / Heating

3: 91 percent / hydrogen / 5 percent Pd/C / ethanol / 0.28 h / 760 Torr / Ambient temperature

4: 93.6 percent / N-bromosuccinimide, dibenzoylperoxide, α,α'-azoisobutyronitrile / CCl4 / 3 h / Heating; Irradiation

With N-Bromosuccinimide; azobisisobutyronitrile; hydrogen; sodium methylate; N,N-dimethyl-aniline; trichlorophosphate; dibenzoyl peroxide; palladium on activated charcoal; In methanol; tetrachloromethane; ethanol;

DOI:10.1002/hlca.19810640114

Reference yield:

2-(4-methylphenyl)-4,6-dichloropyrimidine (21139-61-7) → 2-(4-Bromomethyl-phenyl)-pyrimidine (77232-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / hydrogen / 5 percent Pd/C / ethanol / 0.28 h / 760 Torr / Ambient temperature

2: 93.6 percent / N-bromosuccinimide, dibenzoylperoxide, α,α'-azoisobutyronitrile / CCl4 / 3 h / Heating; Irradiation

With N-Bromosuccinimide; azobisisobutyronitrile; hydrogen; dibenzoyl peroxide; palladium on activated charcoal; In tetrachloromethane; ethanol;

DOI:10.1002/hlca.19810640114

upstream raw materials:

2-p-tolyl-pyrimidine

p-methylbenzamidine hydrochloride

2-(4-methylphenyl)-4,6-dichloropyrimidine

2-(4-methylphenyl)-4,6-dihydroxypyrimidine

Downstream raw materials:

(4-Chloro-phenyl)-[1-(4-pyrimidin-2-yl-phenyl)-meth-(E)-ylidene]-amine

2-{4-[(E)-2-(4-Pyrimidin-2-yl-phenyl)-vinyl]-phenyl}-benzooxazole

Refernces