D-6-OXO-PIPECOLINIC ACID

Base Information

• Chemical Name: D-6-OXO-PIPECOLINIC ACID
• CAS No.: 72002-30-3
• Molecular Formula: C6H9 N O3
• Molecular Weight: 143.142
• Hs Code.: 2933790090
• Mol file: 72002-30-3.mol

Synonyms:2-Piperidinecarboxylicacid, 6-oxo-, (R)-; D-Pyrohomoglutamic acid

Chemical Property of D-6-OXO-PIPECOLINIC ACID

Chemical Property:

• Vapor Pressure: 7.39E-09mmHg at 25°C
• Refractive Index: 1.498
• Boiling Point: 437°C at 760 mmHg
• PKA: 3.59±0.20(Predicted)
• Flash Point: 218.1°C
• PSA: 66.40000
• Density: 1.286g/cm³
• LogP: 0.06850
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(R)-6-Oxopiperidine-2-carboxylicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-6-OXO-PIPECOLINIC ACID

There total 4 articles about D-6-OXO-PIPECOLINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-2-aminoadipic acid (7620-28-2) → (R)-6-oxo-piperidine-2-carboxylic acid (72002-30-3)

Guidance literature:

With water;

DOI:10.1021/ja01104a509

Reference yield:

(R,S)-2-aminoadipic acid (542-32-5) → (R)-6-oxo-piperidine-2-carboxylic acid (72002-30-3)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH solution

2: mit Hilfe eines Enzym-Praeparats aus Schweine-Nieren

3: H₂O

With sodium hydroxide; water;

DOI:10.1021/ja01104a509

Reference yield:

(+/-)-2-chloroacetaminohexanedioic acid (24325-12-0) → (R)-6-oxo-piperidine-2-carboxylic acid (72002-30-3)

Guidance literature:

Multi-step reaction with 2 steps

1: mit Hilfe eines Enzym-Praeparats aus Schweine-Nieren

2: H₂O

With water;

DOI:10.1021/ja01104a509

upstream raw materials:

D-2-aminoadipic acid

water

(R,S)-2-aminoadipic acid

(+/-)-2-chloroacetaminohexanedioic acid

Downstream raw materials:

methyl (R)-6-oxopiperidine-2-carboxylate

Refernces

• 1、 Akasaka, Kozo,Akamatsu, Hiroshi,Kimoto, Yuichi,Komatsu, Yuki,Shimizu, Toshikazu,Shimomura, Naoyuki,Tagami, Katsuya,Negi, Shigeto. "Synthesis of a new dual metalloprotease inhibitor. I. Diastereoselective alkylation of protected 6-oxopipecolic acid esters". . p. 1525 - 1531. Retrieved 2007/10/03.