(3-Bromophenoxy)(tert-butyl)dimethylsilane

Base Information

• Chemical Name: (3-Bromophenoxy)(tert-butyl)dimethylsilane
• CAS No.: 65423-56-5
• Molecular Formula: C12H19 Br O Si
• Molecular Weight: 287.272
• Hs Code.: 2931900090
• European Community (EC) Number: 680-922-3
• DSSTox Substance ID: DTXSID50460296
• Nikkaji Number: J940.153I
• Wikidata: Q82284298
• Mol file: 65423-56-5.mol

Synonyms:65423-56-5;(3-Bromophenoxy)(tert-butyl)dimethylsilane;1-BROMO-3-(TERT-BUTYLDIMETHYLSILOXY)BENZENE;(3-bromophenoxy)-tert-butyl-dimethylsilane;3-Bromophenyl tert-Butyldimethylsilyl Ether;(3-bromophenoxy)-tert-butyldimethylsilane;C12H19BrOSi;Silane, (3-bromophenoxy)(1,1-dimethylethyl)dimethyl-;3-(tert-Butyldimethylsiloxy)bromobenzene;SCHEMBL232409;DTXSID50460296;BFRHMVJJJGUHDI-UHFFFAOYSA-N;3-t-butyldimethylsilyloxybromobenzene;MFCD01318106;3-Bromophenoxy(T-Butyl)Dimethylsilane;AKOS015909893;3-(t-Butyldimethylsilyloxy)bromobenzene;3-Bromophenoxy-tert-butyldimethylsilane;AM87123;3-bromo-(o-tert-butyldimethylsilyl)phenol;3-bromophenoxy-tert-butyl(dimethyl)silane;BS-22689;CS-0035464;FT-0607466;(3-bromo-phenoxy)-tert-butyl-dimethyl-silane;(3-Bromophenoxy)-(tert-butyl)-dimethylsilane;EN300-317505;W12986;A867670;(3-Bromophenoxy) (1,1-dimethylethyl)dimethylsilane;[(3-bromophenyl)oxy](1,1-dimethylethyl)-dimethylsilane

Chemical Property of (3-Bromophenoxy)(tert-butyl)dimethylsilane

Chemical Property:

• Vapor Pressure: 0.0156mmHg at 25°C
• Refractive Index: 1.5090
• Boiling Point: 66°C 0,3mm
• Flash Point: 66°C/0.3mm
• PSA: 9.23000
• Density: 1.158g/cm³
• LogP: 4.83310
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive
• Solubility.: Chloroform, DIchloromethane, Ethyl Acetate
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 286.03885
• Heavy Atom Count: 15
• Complexity: 210

Purity/Quality:

99% ^*data from raw suppliers

3-Bromophenyl tert-Butyldimethylsilyl Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/38:Irritating to eyes and skin.
• Hazard Codes: R36/38:Irritating to eyes and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OC1=CC(=CC=C1)Br
• Uses: Enzyme inhibitor.

Technology Process of (3-Bromophenoxy)(tert-butyl)dimethylsilane

There total 9 articles about (3-Bromophenoxy)(tert-butyl)dimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Bromophenol (591-20-8) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene (65423-56-5)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

DOI:10.1002/jhet.5570320622

Reference yield: 93.7%

(3,5-dibromophenoxy)-tert-butyldimethylsilane (136386-79-3) + 2-Methyl-phenylcyanat (1123-89-3) → C13H18BrNOSi (1089178-86-8) + 1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene (65423-56-5)

Guidance literature:

(3,5-dibromophenoxy)-tert-butyldimethylsilane; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 - 65 ℃;

2-Methyl-phenylcyanat; In tetrahydrofuran; n-heptane; at 10 ℃;

Reference yield: 5.0%

→ 1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene (65423-56-5)

Guidance literature:

upstream raw materials:

3-Bromophenol

tert-butyldimethylsilyl chloride

1,3-dibromobenzene

1H-imidazole

Downstream raw materials:

1,1-Di(2-pyridyl)-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methanol

[3-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-((1S,2S,3R,4R)-3-hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-2-yl)-methanol

4-(3-((tert-butyldimethylsilyl)oxy)phenyl)<4.4.1>propella-2,8-diene-11-carboxylic acid

(3-{[tert-butyl(dimethyl)silyl]oxy}phenyl)boronic acid

Refernces

• 1、 Chan, Jefferson,Ibarra, Gabriela E.,Krishnamurthy, Vishnu,Pino, Nicholas W.,Smaga, Lukas P.. "A Photoactivatable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold to Arrest Cell Migration". supporting information. . Retrieved 2020/01/31.
• 2、 -. "Compound". Paragraph 0177-0179. . Retrieved 2020/05/02.