N,N-diisopropyl-N′-tosylformimidamide

Base Information

• Chemical Name: N,N-diisopropyl-N′-tosylformimidamide
• CAS No.: 1209499-73-9
• Molecular Formula: C₁₄H₂₂N₂O₂S
• Molecular Weight: 282.407
• Mol file: 1209499-73-9.mol

Synonyms:N,N-diisopropyl-N′-tosylformimidamide

Chemical Property of N,N-diisopropyl-N′-tosylformimidamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-diisopropyl-N′-tosylformimidamide

There total 3 articles about N,N-diisopropyl-N′-tosylformimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-toluenesulfonyl azide (941-55-9) + N-ethyl-N,N-diisopropylamine (7087-68-5) → N,N-diisopropyl-N′-tosylformimidamide (1209499-73-9)

Guidance literature:

With tris(2,2'-bipyridyl)ruthenium dichloride; oxygen; In 1,4-dioxane; at 20 ℃; for 6h; under 760.051 Torr; Irradiation;

DOI:10.1039/d0ra10517a

Reference yield: 76.0%

triisopropylamine (3424-21-3) + p-toluenesulfonyl chloride (98-59-9) → N,N-diisopropyl-N′-tosylformimidamide (1209499-73-9)

Guidance literature:

With sodium azide; copper(ll) bromide; In 1,2-dichloro-ethane; at 70 ℃; for 3h;

DOI:10.1002/ejoc.201901048

Reference yield: 43.0%

4-toluenesulfonyl azide (941-55-9) + N,N-diisorpopylformamide (2700-30-3) → N,N-diisopropyl-N′-tosylformimidamide (1209499-73-9)

Guidance literature:

With carbon monoxide; palladium diacetate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In toluene; acetonitrile; at 40 ℃; for 20h; Inert atmosphere;

DOI:10.1021/acs.joc.6b02894

upstream raw materials:

4-toluenesulfonyl azide

N-ethyl-N,N-diisopropylamine

N,N-diisorpopylformamide

triisopropylamine

Refernces

• 1、 Bi, Wen-Zhu,Zhang, Wen-Jie,Li, Zi-Jie,Xia, Xiao-Yi,Chen, Xiao-Lan,Qu, Ling-Bo,Zhao, Yu-Fen. "Air-Induced One-Pot Synthesis of N-Sulfonylformamidines from Sulfonyl Chlorides, NaN3, and Tertiary/Secondary Amines". supporting information. p. 6071 - 6076. Retrieved 2019/09/09.
• 2、 Xu, Xiaoliang,Ge, Zhichuang,Cheng, Dongping,Lei, Ma.,Lu, Chunshan,Zhang, Qunfeng,Yao, Nan,Li, Xiaonian. "CuCI/CCI4-Promoted Convenient Synthesis of Sulfonyl Amidines from Tertiary Amines and Sulfonyl Azides". supporting information; experimental part. p. 897 - 899. Retrieved 2010/06/13.