Technology Process of tricyclo<3.3.1.13,7>dec-2-yl *,R*)>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,11-trioxo-7-phenyl-12-oxa-2,5,8-triazatridecanoate
There total 11 articles about tricyclo<3.3.1.13,7>dec-2-yl *,R*)>-3-(1H-indol-3-ylmethyl)-3-methyl-4,9,11-trioxo-7-phenyl-12-oxa-2,5,8-triazatridecanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
ethyl acetate;
for 4h;
Ambient temperature;
DOI:10.1021/jm00105a062
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 100 percent / pyridine / CH2Cl2 / 2 h / Ambient temperature
2: 89 percent / Et3N / tetrahydrofuran / 0.25 h
3: 90 percent / LiOH / H2O; dioxane / 18 h / Ambient temperature
4: 1.) 1-hydroxybenzotriazole hydrate, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2 h, 2.) 18 h
5: 89 percent / H2 / Pearlman's catalyst / ethanol / 18 h / 25 °C / 2327.2 Torr
6: 43 percent / Et3N / ethyl acetate / 4 h / Ambient temperature
With
pyridine; lithium hydroxide; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide;
palladium dihydroxide;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm00105a062
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 87 percent / Et3N / tetrahydrofuran / 18 h / Ambient temperature
2: Et3N / CH2Cl2 / 18 h / Ambient temperature
3: NaN3 / dimethylformamide / 3 h / 80 °C
4: Lindlar catalyst, H2 / ethyl acetate / 6 h / 30 °C / 2327.2 Torr
5: 1.) 1-hydroxybenzotriazole hydrate, N,N'-dicyclohexylcarbodiimide / 1.) EtOAc, RT, 2 h, 2.) 18 h
6: 89 percent / H2 / Pearlman's catalyst / ethanol / 18 h / 25 °C / 2327.2 Torr
7: 43 percent / Et3N / ethyl acetate / 4 h / Ambient temperature
With
Lindlar's catalyst; sodium azide; hydrogen; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide;
palladium dihydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00105a062
