(4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL

Base Information

• Chemical Name: (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL
• CAS No.: 720706-20-7
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.175
• Hs Code.: 2932999099
• Mol file: 720706-20-7.mol

Synonyms:(4-Aminotetrahydro-2H-pyran-4-yl)methanol;4-Amino-4-hydroxymethyltetrahydropyran;

Chemical Property of (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL

Chemical Property:

• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.474
• Boiling Point: 231 °C at 760 mmHg
• PKA: 14.85±0.10(Predicted)
• Flash Point: 93.5 °C
• PSA: 55.48000
• Density: 1.074 g/cm³
• LogP: 0.18690
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(4-aminooxan-4-yl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Use Description: (4-Amino-tetrahydro-pyran-4-yl)-methanol is a chemical compound with potential applications in various fields. In the field of organic synthesis and pharmaceuticals, it can serve as a building block and intermediate for the synthesis of various organic compounds and pharmaceutical agents, potentially contributing to the development of new drugs for a range of medical conditions. Its role is pivotal in drug discovery and development, aiding in the creation of medications that address diverse health concerns. Additionally, in the realm of chemical research and material science, this compound can be employed as a starting material for the synthesis of specialized materials or as a reagent in chemical reactions, potentially leading to the creation of novel materials with unique properties. Furthermore, in academic and industrial laboratories, it may serve as a reference compound for the study of pyran derivatives and their reactivity, contributing to the advancement of chemical research and understanding. Its multifaceted utility underscores its significance in pharmaceuticals, material development, and scientific investigation, where it plays a crucial role in drug innovation, material synthesis, and chemical analysis.

Technology Process of (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL

There total 5 articles about (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-aminotetrahydropyran-4-carboxylicacid methyl ester (184698-41-7) → (4-aminotetrahydro-2H-pyran-4-yl)methanol (720706-20-7)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 0 - 110 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acscombsci.6b00005

Reference yield:

4-aminotetrahydro-2H-pyran-4-carboxylic acid (39124-20-4) → (4-aminotetrahydro-2H-pyran-4-yl)methanol (720706-20-7)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 0 - 50 °C / Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran;

Reference yield:

4-aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride (217299-03-1) → (4-aminotetrahydro-2H-pyran-4-yl)methanol (720706-20-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

4-aminotetrahydropyran-4-carboxylicacid methyl ester

4-aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride

4-aminotetrahydro-2H-pyran-4-carboxylic acid

Tetrahydro-4H-pyran-4-one

Downstream raw materials:

tert-butyl (4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)carbamate

Refernces

• 1、 Stotani, Silvia,Lorenz, Christoph,Winkler, Matthias,Medda, Federico,Picazo, Edwige,Ortega Martinez, Raquel,Karawajczyk, Anna,Sanchez-Quesada, Jorge,Giordanetto, Fabrizio. "Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening". supporting information. p. 330 - 336. Retrieved 2016/07/06.
• 2、 -. "Quinazoline analogs as receptor tyrosine kinase inhibitors". Page/Page column 25. . Retrieved 2008/06/13.