39124-20-4

Basic information

• Product Name: 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID
• Synonyms: 1,1-AC-PYRAN;4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBOXYLIC ACID;4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID;4-aminotetrahydro-2H-pyran-4-carboxylic acid(SALTDATA: FREE);4-aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride;2H-Pyran-4-carboxylic acid, 4-aMinotetrahydro-;4-aMinooxane-4-carboxylic acid;4-AMino-4-tetrahydropyrancarboxylic acid
• CAS NO: 39124-20-4
• Molecular Formula: C₆H₁₁NO₃
• Molecular Weight: 145.16
• Product Categories: pharmacetical;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 39124-20-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 299.4 °C at 760 mmHg
• Flash Point: 134.9 °C
• Appearance: /
• Density: 1.254 g/cm³
• Vapor Pressure: 0.000282mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Aqueous Base (Slightly), Water (Slightly)
• PKA: 2.06±0.20(Predicted)
• CAS DataBase Reference: 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID(39124-20-4)
• EPA Substance Registry System: 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID(39124-20-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 39124-20-4(Hazardous Substances Data)

Usage

Uses

4-Aminotetrahydro-2H-pyran-4-carboxylic acid has been examined as potential inhibitor of the enzyme S-adenosylmethionine (AdoMet) synthetase.

InChI:InChI=1/C6H11NO3/c7-6(5(8)9)1-3-10-4-2-6/h1-4,7H2,(H,8,9)

Upstream product

• 39124-19-1 8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione 
• 50289-12-8 4-amino-tetrahydro-2H-pyran-4-carbonitrile 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 461-72-3 2,4-imidazolidinedione 

Downstream Products

• 184698-41-7 4-aminotetrahydropyran-4-carboxylicacid methyl ester 
• 720706-20-7 (4-aminotetrahydro-2H-pyran-4-yl)methanol 
• 1367370-17-9 C₃₂H₄₉N₇O₉ 
• 1367370-34-0 C₅₇H₈₆N₁₂O₁₄ 
• 138402-13-8 4-{[(benzyloxy)carbonyl]amino}oxane-4-carboxylic acid 
• 172843-97-9 4-(Boc-amino)tetrahydropyran-4-carboxylic acid 

Relevant articles and documents

A 4 - amino-tetrahydro -2 - pyran -4 - carboxylic acid

The invention discloses a 4 - amino-tetrahydro - 2 - pyran - 4 - carboxylic acid, belongs to a chemical intermediate, its technical point includes the step one, will be four dihydropyrone adding water and in ethanol, then adding ammonium carbonate and sodium cyanide, heated to 60 - 70 °C reaction 3 - 4 h, subsequently cooling down to 5 - 10 °C, filtering and drying after a to the intermediate; step two, the intermediate in a added to the DMF, then adding DMAP, [...] carbon acid di-tert-butyl, heating up to 80 - 100 °C, reaction 16 - 20 h poured into the water after stirring 2 - 3 h, obtained after filtering the intermediate b; step three, the intermediate II by adding in tetrahydrofuran, then adding 40 - 60 wt % of sodium hydroxide solution, heating to reflux 5 - 6 h, steams tetrahydrofuran, then hydrochloric acid for pH adjustment to 2 - 4 after solid precipitation, filtration and drying to obtain the 4 - amino-tetrahydro - 2 - pyran - 4 - carboxylic acid.

PEPTIDYL NITRIL COMPOUNDS AS DIPEPTIDYL PEPTIDASE I INHIBITORS

The invention relates to compounds of Formula (I) and their use as selective dipeptidyl peptidase I inhibitors, as well as pharmaceutical compositions comprising said compounds, and methods of treatment involving said compounds.

PEPTIDES AND PEPTIDOMIMETIC COMPOUNDS, THE MANUFACTURING THEREOF AS WELL AS THEIR USE FOR PREPARING A THERAPEUTICALLY AND/OR PREVENTIVELY ACTIVE PHARMACEUTICAL COMPOSITION

Peptides, peptidomimetics and derivatives thereof of the general formula I: H2N-GHRPX1-β-X4X5X6X7X8X9X10-X11 (I), in which X1-X10 denote one of the 20 genetically coded amino acids, wherein X8, X9 and X10 may also denote a single chemical bond;X11 denotes OR1 in which R1 equals hydrogen or (C1-C10) alkyl NR2R3 with R2 and R3 are equal or different and denote hydrogen, (C1-C10) alkyl, or a residue —W-PEG5-60K, in which the PEG residue is attached via a suitable spacer W to the N-atom, ora residue NH—Y-Z-PEG5-60K, in whichY denotes a chemical bond or a genetically coded amino acids from the group S, C, K or R andZ denotes a spacer, via which a polyethylene glycol (PEG)-residue can be attached, and their physiologically acceptable salts, andβ denotes an amino acid, or a peptidomimetic element, which induces a bend or turn in the peptide backbone.