50289-12-8

Basic information

• Product Name: 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBONITRILE
• Synonyms: 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBONITRILE;4-AMinooxane-4-carbonitrile;4-AMino-tetrahydro-pyran-4-carbonitrile
• CAS NO: 50289-12-8
• Molecular Formula: C₆H₁₀N₂O
• Molecular Weight: 126.16
• Mol File: 50289-12-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 260.777°C at 760 mmHg
• Flash Point: 111.515°C
• Appearance: /
• Density: 1.111g/cm³
• Vapor Pressure: 0.012mmHg at 25°C
• Refractive Index: 1.494
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.71±0.20(Predicted)
• CAS DataBase Reference: 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBONITRILE(50289-12-8)
• EPA Substance Registry System: 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBONITRILE(50289-12-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26
• Hazardous Substances Data: 50289-12-8(Hazardous Substances Data)

Usage

General Description

4-aminotetrahydro-2H-pyran-4-carbonitrile is a chemical compound with the molecular formula C6H8N2O. It is a heterocyclic compound with a pyran ring and a cyano group. 4-AMINOTETRAHYDRO-2H-PYRAN-4-CARBONITRILE is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various pharmaceutical drugs. It has been studied for its potential biological activities and has shown to possess anti-inflammatory and analgesic properties. Additionally, it has been investigated for its potential use as a building block in the synthesis of novel drug molecules. However, further research is needed to fully understand its biological and pharmacological properties.

InChI:InChI=1/C6H10N2O/c7-5-6(8)1-3-9-4-2-6/h1-4,8H2

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 519031-87-9 tert-butyl (4-cyanotetrahydro-2H-pyran-4-yl)carbamate 
• 848821-06-7 4-cyanotetrahydro-2H-pyran-4-carboxylic acid 
• 38041-19-9 4-aminotetrahydropyran 
• 7677-24-9 trimethylsilyl cyanide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 39124-20-4 4-aminotetrahydro-2H-pyran-4-carboxylic acid 
• 184698-41-7 4-aminotetrahydropyran-4-carboxylicacid methyl ester 
• 720706-20-7 (4-aminotetrahydro-2H-pyran-4-yl)methanol 
• 50289-16-2 4-(aminomethyl)tetrahydro-2H-pyran-4-amine 
• 176445-77-5 4-(dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 
• 1284281-42-0 1-(2-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-5-phenyl-1H-pyrazole-3-carboxamide 
• 1284281-61-3 1-(2-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-5-(3-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1284281-60-2 1-(2-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-5-(4-fluorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 1284281-59-9 4-bromo-1-(3-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide 
• 1284281-52-2 N-(4-cyanotetrahydro-2H-pyran-4-yl)-1-(2-phenylphenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide 
• 1284281-51-1 N-(4-cyanotetrahydro-2H-pyran-4-yl)-1-(2-iodophenyl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide 
• 1284281-50-0 1-(4-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide 
• 1284281-49-7 1-(3-bromophenyl)-N-(4-cyanotetrahydro-2H-pyran-4-yl)-4-methyl-5-phenyl-1H-pyrazole-3-carboxamide 
• 1284281-48-6 1-(2-bromophenyl)-4-cyano-N-(4-cyanotetrahydro-2H-pyran-4-yl)-5-phenyl-1H-pyrazole-3-carboxamide 

Relevant articles and documents

2,3-DIHYDRO-1H-PYRROLIZINE-7-FORMAMIDE DERIVATIVE AND APPLICATION THEREOF

The present application relates to a 2,3-dihydro-1H-pyrrolizine-7-formamide derivative as a nucleoprotein inhibitor and a use in preparation of a drug for treating HBV related diseases. The present application specifically relates to a compound represented by formula (II), and isomers or pharmaceutically acceptable salts thereof.

Primary α-tertiary amine synthesis via α-C-H functionalization

A quinone-mediated general synthetic platform for the construction of primary α-tertiary amines from abundant primary α-branched amine starting materials is described. This procedure pivots on the efficient in situ generation of reactive ketimine intermediates and subsequent reaction with carbon-centered nucleophiles such as organomagnesium and organolithium reagents, and TMSCN, creating quaternary centers. Furthermore, extension to reverse polarity photoredox catalysis enables reactivity with electrophiles, via a nucleophilic α-amino radical intermediate. This efficient, broadly applicable and scalable amine-to-amine synthetic platform was successfully applied to library and API synthesis and in the functionalization of drug molecules.

PYRIMIDINE-BASED COMPOUNDS FOR THE TREATMENT OF CANCER

This invention is in the area of pyrimidine-based compounds for the treatment of disorders involving abnormal cellular proliferation, including but not limited to tumors and cancers.