720706-20-7

Basic information

• Product Name: (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL
• Synonyms: 4-AMino-4-hydroxyMethyl-tetrahydro-2H-pyran;4-AMino-4-hydroxyMethyltetrahydropyran;(4-AMino-4-tetrahydropyranyl)Methanol;4-AMino-4-hydroxyMethyl-t...;(4-aminooxan-4-yl)methanol;4-Aminotetrahydro-2H-pyran-4-methanol;(4-AMINOTETRAHYDRO-2H-PYRAN-4-YL)METHANOL;(4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL
• CAS NO: 720706-20-7
• Molecular Formula: C₆H₁₃NO₂
• Molecular Weight: 131.17
• Product Categories: pharmacetical
• Mol File: 720706-20-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 231 °C at 760 mmHg
• Flash Point: 93.5 °C
• Appearance: /
• Density: 1.074 g/cm³
• Vapor Pressure: 0.0121mmHg at 25°C
• Refractive Index: 1.474
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 14.85±0.10(Predicted)
• CAS DataBase Reference: (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL(720706-20-7)
• EPA Substance Registry System: (4-AMINO-TETRAHYDRO-PYRAN-4-YL)-METHANOL(720706-20-7)

Safety Data

• RIDADR: UN1760
• Hazardous Substances Data: 720706-20-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H13NO2/c7-6(5-8)1-3-9-4-2-6/h8H,1-5,7H2

Upstream product

• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 50289-12-8 4-amino-tetrahydro-2H-pyran-4-carbonitrile 
• 39124-20-4 4-aminotetrahydro-2H-pyran-4-carboxylic acid 
• 217299-03-1 4-aminotetrahydro-2H-pyran-4-carboxylic acid hydrochloride 
• 184698-41-7 4-aminotetrahydropyran-4-carboxylicacid methyl ester 

Downstream Products

• 1378810-18-4 2-isopropyl-1-aza-3,8-dioxaspiro[4.5]decane 
• 1029716-09-3 tert-butyl (4-(hydroxymethyl)tetrahydro-2H-pyran-4-yl)carbamate 
• 1350473-46-9 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (4-hydroxymethyltetrahydropyran-4-yl)amide 
• 1207754-85-5 1-[(4-methylphenyl)sulfonyl]-6-oxa-1-azaspiro[2.5]octane 

Relevant articles and documents

NITROGENOUS HETEROCYCLIC COMPOUND, PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND USE

Disclosed are a nitrogenous heterocyclic compound, intermediates, a preparation method, a composition and use thereof. The nitrogenous heterocyclic compound in the present invention is as shown in formula I. The compound has a high inhibitory activity towards ErbB2 tyrosine kinase and a relatively good inhibitory activity towards human breast cancer BT-474 and human gastric cancer cell NCI-N87 which express ErbB2 at a high level, and at the same time has a relatively weak inhibitory activity towards EGFR kinase. Namely, the compound is a highly selective small-molecule inhibitor targeted at ErbB2, and hence it has a high degree of safety, and can effectively enlarge the safety window in the process of taking the drug.

COMPOUNDS

The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example Alzheimer's disease.

Substituted 2-arylimino heterocycles and compositions containing them, for use as progesterone receptor binding agents

This invention relates to 2-arylimino heterocycles, including 2-arylimino-1,3-thiazolidines, 2-arylimino-2,3,4,5-tetrahydro-1,3-thiazines, 2-arylimino-1,3-thiazolidin-4-ones, 2-arylimino-1,3-thiazolidin-5-ones, and 2-arylimino-1,3-oxazolidines, and their use in modulating progesterone receptor mediated processes, and pharmaceutical compositions for use in such therapies.