BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER

Base Information

• Chemical Name: BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER
• CAS No.: 207115-38-6
• Molecular Formula: C10H11IO3
• Molecular Weight: 306.1
• Hs Code.: 2918990090
• Mol file: 207115-38-6.mol

Synonyms:Ethyl 3-iodo-4-methoxybenzoate;

Chemical Property of BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER

Chemical Property:

• Boiling Point: 352.7 °C at 760 mmHg
• Flash Point: 167.1 °C
• PSA: 35.53000
• Density: 1.611 g/cm³
• LogP: 2.47650
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

3-Iodo-4-methoxy-benzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER

There total 4 articles about BENZOIC ACID, 3-IODO-4-METHOXY-, ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-hydroxy-3-iodo-benzoic acid ethyl ester (15126-07-5) + methyl iodide (74-88-4) → ethyl 3-iodo-4-methoxybenzoate (207115-38-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jacs.0c13057

Reference yield:

ethanol (64-17-5) + methyl 3,5-diiodo-4-methoxybenzoate (4253-10-5) → 3-iodo-4-methoxy-benzoic acid methyl ester (35387-93-0) + ethyl 3-iodo-4-methoxybenzoate (207115-38-6)

Guidance literature:

With sodium selenide; sodium tetrahydroborate; for 4h; Yield given. Yields of byproduct given; Heating;

DOI:10.1021/jo972240b

Reference yield:

methyl 4-hydroxy-3,5-diiodobenzoate (3337-66-4) → ethyl 3-iodo-4-methoxybenzoate (207115-38-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / MeONa / dimethylformamide / Ambient temperature

2: Na₂Se, NaBH₄ / 4 h / Heating

With sodium selenide; sodium tetrahydroborate; sodium methylate; In N,N-dimethyl-formamide;

DOI:10.1021/jo972240b

upstream raw materials:

ethanol

3-iodo-4-methoxybenzoic acid

methyl 3,5-diiodo-4-methoxybenzoate

methyl 4-hydroxy-3,5-diiodobenzoate

Downstream raw materials:

ethyl 4-methoxy-3,5-dimethylbenzoate

Refernces

• 1、 Vasil'ev, Andrei A.,Engman, Lars. "Iodothyronine Deiodinase Mimics. Deiodination of o,o'-Diiodophenols by Selenium and Tellurium Reagents". . p. 3911 - 3917. Retrieved 2007/10/03.