2-PYRIDINECARBONITRILE, 3-CHLORO-5-NITRO-

Base Information

• Chemical Name: 2-PYRIDINECARBONITRILE, 3-CHLORO-5-NITRO-
• CAS No.: 488713-30-0
• Molecular Formula: C₆H₂ClN₃O₂
• Molecular Weight: 183.554
• Hs Code.: 2933399090
• Mol file: 488713-30-0.mol

Synonyms:3-Chloro-2-cyano-5-nitropyridine

Chemical Property of 2-PYRIDINECARBONITRILE, 3-CHLORO-5-NITRO-

Chemical Property:

• PSA: 82.50000
• LogP: 2.03808
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-5-nitropicolinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-PYRIDINECARBONITRILE, 3-CHLORO-5-NITRO-

There total 6 articles about 2-PYRIDINECARBONITRILE, 3-CHLORO-5-NITRO- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.8%

2,3-dichloro-5-nitropyridine (22353-40-8) + copper(l) cyanide → 3-chloro-5-nitropyridine-2-carbonitrile (488713-30-0)

Guidance literature:

2,3-dichloro-5-nitropyridine; copper(l) cyanide; In 1-methyl-pyrrolidin-2-one; at 200 ℃; for 1h; Microwave irradiation;

With hydrogenchloride; iron(III) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.666667h;

Reference yield: 18.0%

→ 3-chloro-5-nitropyridine-2-carbonitrile (488713-30-0)

Guidance literature:

Reference yield:

3-chloro-2-iodo-5-nitropyridine (488713-29-7) → 3-chloro-5-nitropyridine-2-carbonitrile (488713-30-0)

Guidance literature:

With copper(l) cyanide; In acetonitrile; at 20 - 80 ℃; for 6h;

upstream raw materials:

3-chloro-2-iodo-5-nitropyridine

tetrabutylammonium nitrate

3-chloro-2-cyanopyridine

2,3-dichloro-5-nitropyridine

Downstream raw materials:

5-amino-3-chloro-2-cyanopyridine

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". . . Retrieved 2016/03/18.
• 2、 -. "Bicyclic modulators of androgen receptor function". . . Retrieved 2008/06/13.