Technology Process of 6-methoxy-4-(4-nitro-phenyl)-1,3-dihydro-naphtho[2,3-c]thiophene 2,2-dioxide
There total 11 articles about 6-methoxy-4-(4-nitro-phenyl)-1,3-dihydro-naphtho[2,3-c]thiophene 2,2-dioxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
chloroform-d1;
regioselective reaction;
DOI:10.1021/ol102861j
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine / 2 h / 20 °C / Inert atmosphere
2.1: ethanol; pyridinium p-toluenesulfonate / 20 °C
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Inert atmosphere; Cooling with ice
4.1: methanol / 0 - 20 °C / Inert atmosphere
5.1: methanol; potassium carbonate / 0.25 h / -20 °C / Inert atmosphere
5.2: 3 h / -20 - 20 °C / Inert atmosphere
6.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere; Cooling with ice
7.1: triethylamine / chloroform-d1
With
methanol; copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); ethanol; carbon tetrabromide; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
methanol; chloroform-d1; dichloromethane;
1.1: Sonogashira coupling / 7.1: Garratt-Braverman cyclization;
DOI:10.1021/ol102861j
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: ethanol; pyridinium p-toluenesulfonate / 20 °C
2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / Inert atmosphere; Cooling with ice
3.1: methanol / 0 - 20 °C / Inert atmosphere
4.1: methanol; potassium carbonate / 0.25 h / -20 °C / Inert atmosphere
4.2: 3 h / -20 - 20 °C / Inert atmosphere
5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere; Cooling with ice
6.1: triethylamine / chloroform-d1
With
methanol; ethanol; carbon tetrabromide; pyridinium p-toluenesulfonate; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine;
In
methanol; chloroform-d1; dichloromethane;
6.1: Garratt-Braverman cyclization;
DOI:10.1021/ol102861j