9-(2',4',6'-trimethoxyphenyl)-9H-xanthene

Base Information

• Chemical Name: 9-(2',4',6'-trimethoxyphenyl)-9H-xanthene
• CAS No.: 102599-53-1
• Molecular Formula: C₂₂H₂₀O₄
• Molecular Weight: 348.398
• Mol file: 102599-53-1.mol

Synonyms:9-(2',4',6'-trimethoxyphenyl)-9H-xanthene

Chemical Property of 9-(2',4',6'-trimethoxyphenyl)-9H-xanthene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 9-(2',4',6'-trimethoxyphenyl)-9H-xanthene

There total 9 articles about 9-(2',4',6'-trimethoxyphenyl)-9H-xanthene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1,2,3-trimethoxybenzene (621-23-8) + xanthene (92-83-1) → 9-(2',4',6'-trimethoxyphenyl)-9H-xanthene (102599-53-1)

Guidance literature:

With tert.-butylhydroperoxide; methanesulfonic acid; In decane; acetone; at 40 ℃; for 18h; Solvent;

DOI:10.1002/anie.201306752

Reference yield: 44.0%

2,4,6-trimethoxybenzaldehyde (830-79-5) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 9-(2',4',6'-trimethoxyphenyl)-9H-xanthene (102599-53-1)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; In tetrahydrofuran; at 0 ℃; for 21h;

DOI:10.1021/ol048298b

Reference yield:

9-hydroxyxanthene (90-46-0) → 9-(2',4',6'-trimethoxyphenyl)-9H-xanthene (102599-53-1)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether; aqueous hydrogen peroxide

2: chloroform; acetic acid

3: chloroform; acetic acid

With diethyl ether; chloroform; dihydrogen peroxide; acetic acid;

upstream raw materials:

9-hydroxyxanthene

1,2,3-trimethoxybenzene

9-chloro-9H-xanthene

xanthen-9-yl hydroperoxide

Refernces

• 1、 Shen, Guodong,Zhao, Lingyu,Wang, Yichen,Xia, Wenfang,Yang, Mingsen,Zhang, Tongxin. "Palladium-copper catalyzed C(sp3)-C(sp2) bond C-H activation cross-coupling reaction: Selective arylation to synthesize 9-aryl-9: H -xanthene and 9,9-diaryl-xanthene derivatives". . p. 84748 - 84751. Retrieved 2016/10/12.
• 2、 Pinter, Aron,Klussmann, Martin. "Sulfonic acid-catalyzed autoxidative carbon-carbon coupling reaction under elevated partial pressure of oxygen". supporting information; experimental part. p. 701 - 711. Retrieved 2012/04/23.