Disodium 2-oxoglutarate

Base Information

• Chemical Name: Disodium 2-oxoglutarate
• CAS No.: 22202-68-2
• Molecular Formula: C5H6 O5 . Na
• Molecular Weight: 168.081
• Hs Code.: 2918300090
• European Community (EC) Number: 206-167-8,241-157-7
• UNII: FLP7P4RM46
• DSSTox Substance ID: DTXSID70944861
• Nikkaji Number: J193.713H
• Wikidata: Q27278059
• Mol file: 22202-68-2.mol

Synonyms:Disodium 2-oxoglutarate;305-72-6;Disodium oxoglurate;disodium 2-oxopentanedioate;sodium 2-oxopentanedioate;disodium;2-oxopentanedioate;2-Ketoglutaric acid sodium salt;2-Oxoglutaric acid disodium salt;Pentanedioic acid, 2-oxo-, disodium salt;EINECS 206-167-8;UNII-FLP7P4RM46;FLP7P4RM46;17091-15-5;2-Ketoglutaric Acid Disodium Salt;Pentanedioic acid, 2-oxo-, sodium salt;Glutaric acid, 2-oxo-, disodium salt;C5H6O5.xNa;C5H6O5.Na;C5-H6-O5.x-Na;C5-H6-O5.Na;alpha-Ketoglutaric acid disodium salt;sodium a-ketoglutarate;Disodium 2-Ketoglutarate;a-ketoglutaric acid sodium;C5H6O5.2Na;SCHEMBL723421;C5-H6-O5.2Na;DTXSID70944861;YBGBJYVHJTVUSL-UHFFFAOYSA-L;|A-Ketoglutaric acid disodium salt;MFCD00043347;DISODIUM .ALPHA.-KETOGLUTARATE;Pentanedioic acid,2-oxo-,sodium salt;AKOS006222087;AS-66431;LS-101641;FT-0612736;K0007;.ALPHA.-OXOGLUTARIC ACID DISODIUM SALT;.ALPHA.-KETOGLUTARIC ACID DISODIUM SALT;D91223;alpha -Ketoglutaric acid disodium salt anhydrous;Q27278059

Chemical Property of Disodium 2-oxoglutarate

Chemical Property:

• PSA: 94.50000
• LogP: -1.82980
• Storage Temp.: 2-8°C
• Solubility.: H2O: 0.5 M at 20 °C, clear, colorless
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 189.98541179
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

98%,99%, ^*data from raw suppliers

α-KetoglutaricAcidMonosodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 4597521
• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(CC(=O)[O-])C(=O)C(=O)[O-].[Na+].[Na+]
• Uses: α-Ketoglutaric acid sodium salt has been used in the human kynurenine amino transferase II (KAT II) inhibition spectra assay.

Technology Process of Disodium 2-oxoglutarate

There total 3 articles about Disodium 2-oxoglutarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17N2O9P (21888-14-2) → pyridoxamine-5'-phosphate (529-96-4) + α-ketoglutaric acid sodium salt (22202-68-2)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 15 ℃; pH=8.0;

DOI:10.1134/S1070363208060212

Reference yield:

α-ketoglutaric acid (328-50-7) → α-ketoglutaric acid sodium salt (22202-68-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; Product distribution / selectivity;

Reference yield:

monosodium L-glutamate (142-47-2) → α-ketoglutaric acid sodium salt (22202-68-2)

Guidance literature:

With glyoxylate; In phosphate buffer; at 30 ℃; for 0.333333h; pH=7.5; Further Variations:; Temperatures; pH-values; Reagents; Enzyme kinetics;

DOI:10.1271/bbb.67.783

upstream raw materials:

monosodium L-glutamate

α-ketoglutaric acid

C₁₃H₁₇N₂O₉P

Downstream raw materials:

octyl α-ketoglutarate

1-benzyl hydrogen 2-oxoglutarate

L-glutamic acid monosodium salt

Glutamic acid

Refernces

• 1、 -. "ALPHA-KETOGLUTARATES AND THEIR USE AS THERAPEUTIC AGENTS". Page/Page column 60; 61; 62; 63. . Retrieved 2008/06/13.