4-FLUORO-N,N-DIMETHYLANILINE

Base Information

• Chemical Name: 4-FLUORO-N,N-DIMETHYLANILINE
• CAS No.: 403-46-3
• Molecular Formula: C8H10FN
• Molecular Weight: 139.173
• Hs Code.: 29163900
• Mol file: 403-46-3.mol

Synonyms:Aniline,p-fluoro-N,N-dimethyl- (6CI,7CI,8CI);4-(Dimethylamino)fluorobenzene;4-Fluoro-N,N-dimethylaniline;N,N-Dimethyl-4-fluoroaniline;p-Fluoro-N,N-dimethylaniline;p-N,N-Dimethylaminofluorobenzene;

Chemical Property of 4-FLUORO-N,N-DIMETHYLANILINE

Chemical Property:

• Melting Point: 36 °C
• Boiling Point: 188.1 °C at 760 mmHg
• Flash Point: 67.5 °C
• PSA: 3.24000
• Density: 1.057 g/cm³
• LogP: 1.89170
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Fluoro-N,N-dimethylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-FLUORO-N,N-DIMETHYLANILINE

There total 30 articles about 4-FLUORO-N,N-DIMETHYLANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-fluoroaniline (371-40-4) → 4-fluoro-N,N-dimethylaniline (403-46-3)

Guidance literature:

With acetic acid; zinc; In 1,4-dioxane; at 30 ℃; for 4h;

DOI:10.1016/j.tetlet.2007.08.092

Reference yield: 96.0%

formic acid (64-18-6) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 4-fluoro-N,N-dimethylaniline (403-46-3)

Guidance literature:

With hydrogen; In toluene; at 140 ℃; for 3h; under 30003 Torr; chemoselective reaction;

DOI:10.1002/cssc.201500869

Reference yield: 92.0%

1-Chloro-4-fluorobenzene (352-33-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-fluoro-N,N-dimethylaniline (403-46-3)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 7,9-bis(2,6-diisopropylphenyl)-7H-acenaphtho[1,2-d]imidazol-9-ium chloride; potassium tert-butylate; In water; toluene; at 35 ℃; for 24h; Glovebox; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.0c03836

upstream raw materials:

dimethyl sulfate

4-fluoroaniline

trimethyl phosphite

methyl iodide

Downstream raw materials:

N,N-dimethyl-p-(p-nitrophenoxy)aniline

C₁₇H₁₅FN₂O

N-(4-fluoro-phenyl)-N-methyl-acetamide

(4-(N,N-dimethylamino)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Refernces

• 1、 Benaissa, Idir,Cantat, Thibault,Genre, Caroline,Godou, Timothé,Pinault, Mathieu. "Additive-free selective methylation of secondary amines with formic acid over a Pd/In2O3 catalyst". . p. 57 - 61. Retrieved 2022/01/19.
• 2、 Hahm, Hyungwoo,Han, Min Su,Hong, Sukwon,Kim, Jiyun,Ryoo, Jeong Yup. "Photocatalytic carbocarboxylation of styrenes with CO2for the synthesis of γ-aminobutyric esters". . p. 6301 - 6312. Retrieved 2021/07/28.