D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE
• CAS No.: 69630-50-8
• Molecular Formula: C₆H₁₁NO₄*ClH
• Molecular Weight: 197.619
• Mol file: 69630-50-8.mol

Synonyms:D-Asparticacid, dimethyl ester, hydrochloride (9CI);Dimethyl D-aspartate hydrochloride;

Chemical Property of D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE

Chemical Property:

• Melting Point: 114-119℃
• PSA: 78.62000
• LogP: 0.55210
• Storage Temp.: −20°C
• Solubility.: Methanol (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

D-Aspartic acid dimethyl ester hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-Aspartic Acid Dimethyl Ester Hydrochloride is a useful synthetic intermediate in the synthesis of MK-7246 (M425045); a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.

Technology Process of D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE

There total 3 articles about D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → dimethyl (R)-2-aminobutanedioate hydrochloride (14358-33-9,32213-95-9,69630-50-8)

Guidance literature:

With acetyl chloride;

DOI:10.1021/jm301058f

Reference yield: 99.9%

chloro-trimethyl-silane (75-77-4) + (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → dimethyl (R)-2-aminobutanedioate hydrochloride (14358-33-9,32213-95-9,69630-50-8)

Guidance literature:

In methanol; at 20 ℃; Cooling;

DOI:10.1021/jm401707t

Reference yield:

dimethyl (S)-malate (617-55-0) → dimethyl L-aspartate hydrochloride (32213-95-9) + dimethyl (R)-2-aminobutanedioate hydrochloride (14358-33-9,32213-95-9,69630-50-8)

Guidance literature:

Multistep reaction. Title compound not separated from byproducts; e.e. = 95percent;

DOI:10.1016/S0040-4039(00)95329-2

upstream raw materials:

dimethyl (S)-malate

methanol

(2R)-aspartic acid

chloro-trimethyl-silane

Downstream raw materials:

dimethyl (R)-N-(triphenylmethyl)aspartate

Dimethyl D-N-benzylaspartate

(R)-5-dimethoxyphosphoryl-4-oxo-N-(triphenylmethyl)norvaline methyl ester

Dimethyl D-N-(9-phenylfluoren-9-yl)-N-benzylaspartate

Refernces

• 1、 Petermichl, Markus,Steinert, Christine,Schobert, Rainer. "A Synthetic Route to the MT1-MMP Inhibitor Ancorinoside D". . p. 730 - 738. Retrieved 2019/01/23.
• 2、 -. "Preparation method of nitrogen-substituted aspartic acid". Paragraph 0045; 0046; 0047; 0048. . Retrieved 2019/01/24.