1-MORPHOLINOPROPAN-1-ONE

Base Information

• Chemical Name: 1-MORPHOLINOPROPAN-1-ONE
• CAS No.: 30668-14-5
• Molecular Formula: C7H13 N O2
• Molecular Weight: 143.186
• Hs Code.: 2934999090
• Mol file: 30668-14-5.mol

Synonyms:Morpholine,4-(1-oxopropyl)- (9CI); Morpholine, 4-propionyl- (6CI,8CI);4-Propionylmorpholine; N-Propanoylmorpholine; N-Propionylmorpholine; NSC 14835

Chemical Property of 1-MORPHOLINOPROPAN-1-ONE

Chemical Property:

• Vapor Pressure: 0.00723mmHg at 25°C
• Boiling Point: 269.5°Cat760mmHg
• Flash Point: 116.8°C
• PSA: 29.54000
• Density: 1.05g/cm³
• LogP: 0.19310

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Morpholinyl)-1-propanone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 1-MORPHOLINOPROPAN-1-ONE

There total 7 articles about 1-MORPHOLINOPROPAN-1-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-Acryloylmorpholine (5117-12-4,28902-82-1) + iodobenzene (591-50-4) → 1-morpholinopropane-1-one (30668-14-5) + 4-cinnamoylmorpholine (16619-19-5)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; P(p-C₆H₄F)3; In 1,4-dioxane; water; at 80 ℃; Sealed tube;

DOI:10.1021/jacs.0c03040

Reference yield: 67.0%

N-Acryloylmorpholine (5117-12-4,28902-82-1) + iodobenzene (591-50-4) → 1-morpholinopropane-1-one (30668-14-5) + 1-(4-morpholinyl)-2-phenyl-1-propanone (155222-99-4)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetramethylammonium formiate; potassium carbonate; P(p-C₆H₄F)3; In 1,4-dioxane; water; at 80 ℃; Sealed tube;

DOI:10.1021/jacs.0c03040

Reference yield: 63.0%

N-Acryloylmorpholine (5117-12-4,28902-82-1) + iodobenzene (591-50-4) → 1-morpholinopropane-1-one (30668-14-5) + 4-cinnamoylmorpholine (16619-19-5) + 1-(4-morpholinyl)-2-phenyl-1-propanone (155222-99-4)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetramethylammonium formiate; P(p-C₆H₄F)3; In water; N,N-dimethyl-formamide; at 80 ℃; Sealed tube;

DOI:10.1021/jacs.0c03040

upstream raw materials:

morpholine

3-benzyloxypropan-1-ol

N-Acryloylmorpholine

iodobenzene

Downstream raw materials:

1-(dimethyl(phenyl)silyl)propan-1-one

2-methyl-1-morpholinoprop-2-en-1-one

N-Acryloylmorpholine

1-phenyl-pent-1-yn-3-one

Refernces

• 1、 Barwick-Silk, James,Hardy, Simon,Willis, Michael C.,Weller, Andrew S.. "Rh(DPEPhos)-Catalyzed Alkyne Hydroacylation Using β-Carbonyl-Substituted Aldehydes: Mechanistic Insight Leads to Low Catalyst Loadings that Enables Selective Catalysis on Gram-Scale". supporting information. p. 7347 - 7357. Retrieved 2018/06/04.
• 2、 -. "N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines". . . Retrieved 2008/06/13.