Technology Process of (R)-2-phenyl-4-oxopentanoic acid
There total 3 articles about (R)-2-phenyl-4-oxopentanoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
methyl 4-keto-2-phenylpentanoate;
With
potassium hydroxide;
In
methanol; water;
at 20 ℃;
for 1h;
Further stages. Title compound not separated from byproducts.;
racemate resolution with (S)-(-)-1-(2-naphthyl)ethylamine;
DOI:10.1021/ja001395p
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: PdCl2; CuCl; O2 / dimethylformamide; H2O / 96 h / 760.05 Torr
2.1: KOH / H2O; methanol / 1 h / 20 °C
2.2: racemate resolution with (S)-(-)-1-(2-naphthyl)ethylamine
With
potassium hydroxide; oxygen; copper(l) chloride; palladium dichloride;
In
methanol; water; N,N-dimethyl-formamide;
1.1: Wacker process;
DOI:10.1021/ja001395p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: LDA / tetrahydrofuran / 1.5 h / -78 °C
1.2: HMPA / tetrahydrofuran / 1 h / -78 °C
2.1: PdCl2; CuCl; O2 / dimethylformamide; H2O / 96 h / 760.05 Torr
3.1: KOH / H2O; methanol / 1 h / 20 °C
3.2: racemate resolution with (S)-(-)-1-(2-naphthyl)ethylamine
With
potassium hydroxide; oxygen; copper(l) chloride; palladium dichloride; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;
2.1: Wacker process;
DOI:10.1021/ja001395p