N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide

Base Information

• Chemical Name: N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide
• CAS No.: 351329-87-8
• Molecular Formula: C₁₄H₂₃NO₂
• Molecular Weight: 237.342
• Mol file: 351329-87-8.mol

Synonyms:N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide

Chemical Property of N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide

There total 1 articles about N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

1-acetamido-3,5-dimethyladamantane (19982-07-1) → N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide (351329-87-8) + 1,3-dihydroxy-5,7-dimethyladamantane (10347-01-0) + 3-amino-5,7-dimethyladamantan-1-ol (63971-25-5)

Guidance literature:

1-acetamido-3,5-dimethyladamantane; With nitric acid;

With acetic acid; urea; In water;

DOI:10.1134/S1070428017070028

Reference yield: 53.6%

N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide (351329-87-8) → 1-hydroxy-3-amino-5,7-dimethyladamantane hydrochloride (356572-08-2)

Guidance literature:

With hydrogenchloride; In water; at 120 ℃; for 47h;

Reference yield:

N-(3-hydroxy-5,7-dimethyladamantan-1-yl)acetamide (351329-87-8) → 1-(benzyloxycarbonyl)amino-3,5-dimethyl-7-hydroxyadamantane (356572-20-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; sodium sulfate / diethylene glycol

2: sodium carbonate; sodium sulfate / water; N,N-dimethyl-formamide

With sodium hydroxide; sodium carbonate; sodium sulfate; In water; N,N-dimethyl-formamide; diethylene glycol;

upstream raw materials:

1-acetamido-3,5-dimethyladamantane

Downstream raw materials:

1-hydroxy-3-amino-5,7-dimethyladamantane hydrochloride

1-(benzyloxycarbonyl)amino-3,5-dimethyl-7-hydroxyadamantane

1,1-dibenzylamino-3,5-dimethyl-7-hydroxy-adamantane

Refernces