FROVATRIPTAN

Base Information

• Chemical Name: FROVATRIPTAN
• CAS No.: 147009-08-3
• Molecular Formula: C14H17 N3 O
• Molecular Weight: 243.308
• Hs Code.: 2933995500
• Mol file: 147009-08-3.mol

Synonyms:2,3,4,9-Tetrahydro-3-(methylamino)-1H-carbazole-6-carboxamide

Chemical Property of FROVATRIPTAN

Chemical Property:

• Boiling Point: 515.2±50.0 °C(Predicted)
• PKA: 16.39±0.40(Predicted)
• PSA: 70.91000
• Density: 1.27±0.1 g/cm3(Predicted)
• LogP: 2.43470

Purity/Quality:

98%Min ^*data from raw suppliers

FROVATRIPTAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FROVATRIPTAN

There total 5 articles about FROVATRIPTAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(methylamino)cyclohexanone-2,2-dimethyltrimethylene ketal hydrochloride (158747-10-5) + C7H9N3O*(x)ClH → 3-methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole (147009-08-3)

Guidance literature:

4-(methylamino)cyclohexanone-2,2-dimethyltrimethylene ketal hydrochloride; C₇H₉N₃O*(x)ClH; With hydrogenchloride; In water; at 65 - 70 ℃;

With sodium hydroxide; In water; at 15 ℃; pH=10;

Reference yield:

(+/-)-6-carboxamide-3-methylamino-1,2,3,4-tetrahydrocarbazole hydrochloride → 3-methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole (147009-08-3)

Guidance literature:

With copper(II) sulfate hydrate; ammonia; In water; butan-1-ol; at 70 ℃; pH=10.5; Product distribution / selectivity; Cooling;

Reference yield:

4-aminobenzamide (2835-68-9) → 3-methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole (147009-08-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; sodium nitrite / water / 1 h / -20 - 0 °C

1.2: Cooling

2.1: hydrogenchloride / water / 65 - 70 °C

2.2: 15 °C / pH 10

With hydrogenchloride; sodium nitrite; In water;

upstream raw materials:

4-aminobenzamide

4-(methylamino)cyclohexanone-2,2-dimethyltrimethylene ketal hydrochloride

3,3-dimethyl-1,5-dioxaspiro[5.5]undecan-9-one

1,4-Cyclohexanedione

Refernces