Carbobenzoxy-D,L-tryptophanamide

Base Information

• Chemical Name: Carbobenzoxy-D,L-tryptophanamide
• CAS No.: 27018-75-3
• Molecular Formula: C19H19N3O3
• Molecular Weight: 337.37
• Mol file: 27018-75-3.mol

Synonyms:N-[(Benzyloxy)carbonyl]tryptophanamide;Propanamide, 2-benzyloxycarbonylamino-3-(3-indolyl)-;

Chemical Property of Carbobenzoxy-D,L-tryptophanamide

Chemical Property:

• Melting Point: 166-168°C
• Boiling Point: 657.7 °C at 760 mmHg
• Flash Point: 351.6 °C
• PSA: 97.21000
• Density: 1.305 g/cm³
• LogP: 3.58190

Purity/Quality:

98%Min ^*data from raw suppliers

Carbobenzoxy-D,L-tryptophanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: An amino acid amide and intermediate in the preparation of L-Tryptophanamide Hydrochloride (Cat. #T89550) An amino acid amide and intermediate in the preparation of L-Tryptophanamide Hydrochloride (Cat. #T89550).

Technology Process of Carbobenzoxy-D,L-tryptophanamide

There total 1 articles about Carbobenzoxy-D,L-tryptophanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

L-tryptophanamide hydrochloride (5022-65-1) + benzyl chloroformate (501-53-1,94274-21-2) → [1-carbamoyl-2-(3-indolyl)-ethyl]-carbamic acid benzyl ester (27018-75-3)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 1.08333h;

Reference yield: 40.0%

[1-carbamoyl-2-(3-indolyl)-ethyl]-carbamic acid benzyl ester (27018-75-3) + 2,3-dicyano-5,6-dichloro-p-benzoquinone (84-58-2) → [1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester (255371-72-3)

Guidance literature:

In tetrahydrofuran; water; for 2.5h;

upstream raw materials:

L-tryptophanamide hydrochloride

benzyl chloroformate

Downstream raw materials:

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester

Refernces