(L)-N-Benzyloxycarbonyl--oxo-tryptophaneamide

Base Information

• Chemical Name: (L)-N-Benzyloxycarbonyl--oxo-tryptophaneamide
• CAS No.: 255371-72-3
• Molecular Formula: C₁₉H₁₇N₃O₄
• Molecular Weight: 351.362
• Mol file: 255371-72-3.mol

Synonyms:[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester

Chemical Property of (L)-N-Benzyloxycarbonyl--oxo-tryptophaneamide

Chemical Property:

• Melting Point: 186-188°C
• Boiling Point: 680.1±55.0 °C(Predicted)
• PKA: 9.92±0.46(Predicted)
• Density: 1.366±0.06 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N-Benzyloxycarbonyl-β-oxo-tryptophaneamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: An amino acid amide

Technology Process of (L)-N-Benzyloxycarbonyl--oxo-tryptophaneamide

There total 1 articles about (L)-N-Benzyloxycarbonyl--oxo-tryptophaneamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

[1-carbamoyl-2-(3-indolyl)-ethyl]-carbamic acid benzyl ester (27018-75-3) + 2,3-dicyano-5,6-dichloro-p-benzoquinone (84-58-2) → [1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester (255371-72-3)

Guidance literature:

In tetrahydrofuran; water; for 2.5h;

Reference yield: 85.0%

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester (255371-72-3) + 2,4-Dimethoxybenzaldehyde (613-45-6) → 2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide (255371-90-5)

Guidance literature:

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In ethanol; acetic acid; ethyl acetate; for 3h; under 760.051 Torr;

2,4-Dimethoxybenzaldehyde; With sodium tris(acetoxy)borohydride; In DMF (N,N-dimethyl-formamide); acetic acid; at 20 ℃; for 18h;

Reference yield: 75.0%

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester (255371-72-3) + 2,4,6-trimethoxybenzaldehyde (830-79-5) → 3-(3-indolyl)-3-oxo-2-(2,4,6-trimethoxybenzylamino)propionamide (255372-00-0)

Guidance literature:

[1-carbamoyl-2-(3-indolyl)-2-oxoethyl]carbamic acid benzyl ester; With hydrogen; palladium 10% on activated carbon; In ethanol; acetic acid; ethyl acetate; for 15h; under 760.051 Torr;

2,4,6-trimethoxybenzaldehyde; With sodium tris(acetoxy)borohydride; In DMF (N,N-dimethyl-formamide); acetic acid; at 20 ℃; for 18h;

upstream raw materials:

[1-carbamoyl-2-(3-indolyl)-ethyl]-carbamic acid benzyl ester

2,3-dicyano-5,6-dichloro-p-benzoquinone

Downstream raw materials:

2-(2,4-dimethoxybenzylamino)-3-(3-indolyl)-3-oxo-propionamide

3-(3-indolyl)-3-oxo-2-(2,4,6-trimethoxybenzylamino)propionamide

Refernces