2-Chloro-1,3-thiazole-4-carboxylic acid

Base Information

• Chemical Name: 2-Chloro-1,3-thiazole-4-carboxylic acid
• CAS No.: 5198-87-8
• Molecular Formula: C4H2ClNO2S
• Molecular Weight: 163.5822
• Hs Code.: 2934100090
• Mol file: 5198-87-8.mol

Synonyms:Thiazolecarboxylic acid, 2-chloro-;

Chemical Property of 2-Chloro-1,3-thiazole-4-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 220 °C
• Refractive Index: 1.634
• Boiling Point: 370.208 °C at 760 mmHg
• PKA: 3.15±0.10(Predicted)
• Flash Point: 177.696 °C
• PSA: 78.43000
• Density: 1.693 g/cm³
• LogP: 1.49470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

2-Chloro-1,3-thiazole-4-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-1,3-thiazole-4-carboxylic acid

There total 5 articles about 2-Chloro-1,3-thiazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2-chlorothiazole-4-carboxylic acid (5198-87-8)

Guidance literature:

Reference yield: 60.0%

2-chloro-thiazole-4-carboxylic acid ethyl ester (41731-52-6) → 2-chlorothiazole-4-carboxylic acid (5198-87-8)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃;

Reference yield: 55.0%

2-amino-1,3-thiazole-4-carboxylic acid (40283-41-8) → 2-chlorothiazole-4-carboxylic acid (5198-87-8)

Guidance literature:

2-amino-1,3-thiazole-4-carboxylic acid; With hydrogenchloride; sodium nitrite; In 1,4-dioxane; water; at 0 - 5 ℃; for 2h;

With copper(l) chloride; In 1,4-dioxane; water; at 0 - 20 ℃; for 8h;

upstream raw materials:

2-chloro-thiazole-4-carboxylic acid ethyl ester

Ethyl-2-nitrothiazol-4-carboxylat

methyl 2-chlorothiazole-4-carboxylate

2-amino-1,3-thiazole-4-carboxylic acid

Downstream raw materials:

2-chloro-thiazole-4-carboxylic acid 3,5-difluoro-4-methanesulfonylamino-benzylamide

tert-butyl 2-chlorothiazol-4-ylcarbamate

3-(2-chloro-1,3-thiazol-4-yl)-1-{2-[4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}urea

Refernces

• 1、 -. "PYRIDAZINE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS". Page/Page column 126; 127. . Retrieved 2011/02/24.
• 2、 -. "AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND PEST CONTROLLING METHOD". Page/Page column 460; 461. . Retrieved 2011/06/24.