41731-52-6

Basic information

• Product Name: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE;ETHYL 2-CHLOROTHIAZOLE-4-CARBOXYLATE;2-Chlorothiazole-4-carboxylic acid ethyl ester;2-Chloro-4-(ethoxycarbonyl)-1,3-thiazole;4-Thiazolecarboxylic acid, 2-chloro-, ethyl ester;Ethyl 2-chloro-4-thiazolecarboxylate;2-Chloro-thiazole-4-carboxylic acid Methyl ester;2-chloro-4-Thiazolecarboxylic acid ethyl ester
• CAS NO: 41731-52-6
• Molecular Formula: C₆H₆ClNO₂S
• Molecular Weight: 191.637
• Product Categories: Building Blocks;Thiazole
• Mol File: 41731-52-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 283.9℃
• Flash Point: 125.5℃
• Appearance: /
• Density: 1.383
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.50±0.10(Predicted)
• CAS DataBase Reference: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE(41731-52-6)
• EPA Substance Registry System: ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE(41731-52-6)

Safety Data

• Hazardous Substances Data: 41731-52-6(Hazardous Substances Data)

Usage

General Description

ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE is a compound with the chemical formula C7H7ClNO2S. It is a chlorinated thiazole derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. This chemical is an ester, meaning it contains a carbonyl group bonded to an oxygen atom, and its structure includes a thiazole ring, which consists of sulfur and nitrogen atoms. Ethyl 2-chloro-1,3-thiazole-4-carboxylate is known for its strong odor and is classified as a hazardous substance, requiring careful handling and storage to prevent exposure and potential health risks.

Upstream product

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Downstream Products

• 5198-87-8 2-chlorothiazole-4-carboxylic acid 
• 1392426-83-3 ethyl 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxylate 
• 101012-12-8 2-chloro-1,3-thiazole-5-carboxylic acid 
• 867065-53-0 4-(4-ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester 
• 57677-79-9 ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate 
• 132089-35-1 ethyl 2-(4-fluorophenyl)thiazole-4-carboxylate 
• 175204-88-3 2-[4-(trifluoromethyl)phenyl]thiazole-4-carboxylic acid ethyl ester 
• 922516-49-2 ethyl 2-(1-piperazinyl)-4-thiazolecarboxylate monohydrochloride 
• 660449-97-8 ethyl 2-(3-(((tert-butoxycarbonyl)amino)methyl)-2-isobutyl-4-(4-methylphenyl)quinolin-6-yl)-1,3-thiazole-4-carboxylate 
• 928256-35-3 2-chlorothiazol-4-carboxamide 
• 153027-86-2 ethyl 2-fluorothiazole-4-carboxylate 
• 5198-85-6 (2-chlorothiazol-4-yl)methanol 

Relevant articles and documents

Photoredox-mediated C-H functionalization and coupling of tertiary aliphatic amines with 2-chloroazoles

Herein, conditions for C-H functionalization of tertiary aliphatic amines and their subsequent coupling with a number of 2-chloroazole derivatives are reported. The reaction is facilitated by a catalytic amount of tris-fac-Ir(ppy)3, with blue light irradiation and takes place under mild and convenient conditions. Most couplings take place with excellent regioselectivity. The reaction is tolerant of a number of functional groups and allows for rapid access to α-azole carbinamines commonly found in post-translationally modified peptides.

Tuning and predicting biological affinity: Aryl nitriles as cysteine protease inhibitors

A series of aryl nitrile-based ligands were prepared to investigate the effect of their electrophilicity on the affinity against the cysteine proteases rhodesain and human cathepsin L. Density functional theory calculations provided relative reactivities of the nitriles, enabling prediction of their biological affinity and cytotoxicity and a clear structure-activity relationship.

Dihydropyrimidine Compounds and Their Uses in Preparation of Medicaments for Treating and Preventing Antiviral Diseases

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or