5198-87-8

Basic information

• Product Name: 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID
• Synonyms: 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID;2-Chloro-4-thiazolecarboxylic acid;4-Carboxy-2-chloro-1,3-thiazole;4-Thiazolecarboxylic acid, 2-chloro-;2-Chlorothiazole-4-Carboxylic Acid(WXC02298)
• CAS NO: 5198-87-8
• Molecular Formula: C4H2ClNO2S
• Molecular Weight: 163.58
• Product Categories: Organohalides;Thiazole
• Mol File: 5198-87-8.mol
• Article Data: 10

Chemical Properties

• Melting Point: 220 °C
• Boiling Point: 370.208 °C at 760 mmHg
• Flash Point: 177.696 °C
• Appearance: White to yellow/Crystalline Powder
• Density: 1.693 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.634
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 3.15±0.10(Predicted)
• CAS DataBase Reference: 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID(5198-87-8)
• EPA Substance Registry System: 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLIC ACID(5198-87-8)

Safety Data

• Hazard Codes: Xi
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5198-87-8(Hazardous Substances Data)

Usage

General Description

2-Chloro-1,3-thiazole-4-carboxylic acid is a chemical compound with the molecular formula C5H3ClNO2S. It is a chlorinated carboxylic acid derivative of thiazole, containing a chlorine atom, a carboxylic acid group, and a thiazole ring. 2-Chloro-1,3-thiazole-4-carboxylic acid is used in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It has potential applications in medicinal chemistry, as it can be used as a building block for the synthesis of biologically active molecules. Additionally, it has been studied for its antimicrobial and antifungal properties, making it a potentially valuable compound in the development of new drugs and agricultural products.

InChI:InChI=1/C4H2ClNO2S/c5-4-6-2(1-9-4)3(7)8/h1H,(H,7,8)

Upstream product

• 43028-99-5 Ethyl-2-nitrothiazol-4-carboxylat 
• 40283-41-8 2-amino-1,3-thiazole-4-carboxylic acid 
• 850429-61-7 methyl 2-chlorothiazole-4-carboxylate 
• 41731-52-6 2-chloro-thiazole-4-carboxylic acid ethyl ester 

Downstream Products

• 1202643-24-0 2-chloro-thiazole-4-carboxylic acid 3,5-difluoro-4-methanesulfonylamino-benzylamide 
• 1617505-27-7 3-(2-chloro-1,3-thiazol-4-yl)-1-{2-[4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]phenyl}urea 
• 1258934-67-6 tert-butyl 2-chlorothiazol-4-ylcarbamate 

Relevant articles and documents

Salt of nitrogen-containing heteroaromatic derivative and crystal form thereof

The invention relates to a salt of a nitrogen-containing heteroaromatic derivative and a crystal form thereof. The invention specifically relates to a salt with a general formula (I) and a crystal form thereof. A preparation method and a pharmaceutical composition containing the salt of the derivative and a crystal form thereof, as a protein tyrosine phosphatase - 2C (SHP2) inhibitor, and application thereof to treatment of diseases or diseases such as leukemia, neuroblastoma, melanoma, breast cancer, lung cancer and colon cancer.

AMIDE DERIVATIVE, PEST CONTROL AGENT CONTAINING THE AMIDE DERIVATIVE AND PEST CONTROLLING METHOD

A pest control agent containing a compound represented by the following Formula (1), wherein A represents a carbon atom, a nitrogen atom, or the like, K represents a non-metal atom group necessary for forming a cyclic linking group derived from a 5- or 6-membered aromatic ring, in combination with A and two carbon atoms to which A bonds, X represents a hydrogen atom, a halogen atom, or the like, n represents an integer of from 0 to 4, T represents -C(=G1)-Q1 (wherein G1 and G2 represent an oxygen atom or the like, Q1 represents a phenyl group which may have a substituent, a heterocyclic group which may have a substituent, or the like), or the like, Q2 represents a phenyl group or the like, G3 represents an oxygen atom or the like, and R1 and R2 each independently represent a hydrogen atom, a C1-C6 alkyl group, or a group represented by -L-D, or the like (provided that at least either R1 or R2 represents a group represented by -L-D); as an active ingredient exhibits an excellent effect.

NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

This present invention relates to novel compounds, isomer thereof or pharmaceutically acceptable salts thereof as vanilloid receptor (Vanilloid Receptor 1; VR1; TRPV1) antagonist; and a pharmaceutical composition containing the same. The present invention provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.