METHYLTHIOMETHYL PHENYL SULFONE

Base Information

• Chemical Name: METHYLTHIOMETHYL PHENYL SULFONE
• CAS No.: 59431-14-0
• Molecular Formula: C8H10O2S2
• Molecular Weight: 202.298
• Mol file: 59431-14-0.mol

Synonyms:METHYLTHIOMETHYL PHENYL SULFONE;LABOTEST-BB LT00452176

Chemical Property of METHYLTHIOMETHYL PHENYL SULFONE

Chemical Property:

• Vapor Pressure: 5.26E-05mmHg at 25°C
• Melting Point: 85-87 °C(lit.)
• Refractive Index: 1.567
• Boiling Point: 358.4°C at 760 mmHg
• Flash Point: 170.6°C
• PSA: 67.82000
• Density: 1.251g/cm³
• LogP: 2.86160

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methylthiomethyl phenyl sulfone 99% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methylthiomethyl phenyl sulfone may be employed:as nucleophilic and electrophilic building block, in the asymmetric synthesis of 6-N-benzoyl-5′-O-benzyl-2′-deoxyadenosine and its anomerin the synthesis of various multidentate methylthio arylethynes (MTA) derivativesas starting reagent in the preparation of methylthio arylbutadiynes (Ar-C=C-C=C-SCH3)

Technology Process of METHYLTHIOMETHYL PHENYL SULFONE

There total 12 articles about METHYLTHIOMETHYL PHENYL SULFONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

chloromethyl phenyl sulfone (7205-98-3) + sodium thiomethoxide (5188-07-8) → (methylsulfanyl)methyl phenyl sulfone (59431-14-0)

Guidance literature:

In ethanol;

DOI:10.1016/S0040-4020(01)90393-X

Reference yield: 80.0%

methanethiosulfonic acid S-methyl ester (2949-92-0,31761-75-8) + 2-(phenylsulfonyl)acetophenone (3406-03-9) → (methylsulfanyl)methyl phenyl sulfone (59431-14-0)

Guidance literature:

With sodium carbonate; In ethanol; Heating;

DOI:10.1016/S0040-4020(01)90393-X

Reference yield: 80.0%

2-(phenylsulfonyl)acetophenone (3406-03-9) + S-methyl p-chlorobenzenethiosulfonate (68305-26-0) → (methylsulfanyl)methyl phenyl sulfone (59431-14-0)

Guidance literature:

With sodium carbonate; In ethanol; Heating;

DOI:10.1016/S0040-4020(01)90393-X

upstream raw materials:

ethyl (methylsulfanyl)phenylsulfonylacetate

methanethiosulfonic acid S-methyl ester

2-(phenylsulfonyl)acetophenone

(methylthio)methyl acetate

Downstream raw materials:

methylsulphonyl(phenylsulphonyl)methane

phenyl- sulfone

(1-(4-nitro)phenyl)-3-acetyloxyl-4-methylthio-4-phenylsulphonyl butyne

(methylsulfinyl)methyl phenyl sulfone

Refernces

• 1、 Marzorati, Liliana,Yoshikawa, Eduardo K.C.,Braga, Ataualpa A.C.,Di Vitta, Claudio. "On the thermal Pummerer rearrangement of substituted sulfoxides". . p. 248 - 260. Retrieved 2014/04/03.
• 2、 Ogura, Katsuyuki,Yahata, Nobuhiro,Watanabe, Jun-ichi,Takahashi, Kazumasa,Iida, Hirotada. "Convenient Preparation of Methylthiomethyl p-Tolyl Sulfone Starting from Dimethyl Sulfoxide". . p. 3543 - 3544. Retrieved 2007/10/02.