3-[4-(Benzyloxy)phenyl]propionic acid

Base Information

• Chemical Name: 3-[4-(Benzyloxy)phenyl]propionic acid
• CAS No.: 50463-48-4
• Molecular Formula: C16H16O3
• Molecular Weight: 256.301
• Hs Code.: 2918990090
• Mol file: 50463-48-4.mol

Synonyms:3-[4-(benzyloxy)phenyl]propanoic acid (IM OCS);3-[4-(benzyloxy)phenyl]propanoic acid;

Chemical Property of 3-[4-(Benzyloxy)phenyl]propionic acid

Chemical Property:

• Vapor Pressure: 3.91E-08mmHg at 25°C
• Melting Point: 116-118℃
• Refractive Index: 1.585
• Boiling Point: 429.3 °C at 760 mmHg
• Flash Point: 159.4 °C
• PSA: 46.53000
• Density: 1.175 g/cm³
• LogP: 3.28280

Purity/Quality:

98%min ^*data from raw suppliers

3-(4-Benzyloxyphenyl)propionicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[4-(Benzyloxy)phenyl]propionic acid

There total 21 articles about 3-[4-(Benzyloxy)phenyl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-hydroxyphenylpropionic acid (501-97-3) + benzyl bromide (100-39-0) → 3-(4-benzyloxyphenyl)propanoic acid (50463-48-4)

Guidance literature:

With sodium hydroxide; water; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; at 20 - 80 ℃;

DOI:10.1021/jm8007322

Reference yield: 98.0%

methyl 3-(4-benzyloxyphenyl)propanoate (24807-40-7) → 3-(4-benzyloxyphenyl)propanoic acid (50463-48-4)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm0155502

Reference yield: 97.0%

3-(4-benzyloxyphenyl)propionic acid benzyl ester (58608-97-2) → 3-(4-benzyloxyphenyl)propanoic acid (50463-48-4)

Guidance literature:

With methanol; water; potassium hydroxide; In tetrahydrofuran; at 20 - 60 ℃; for 4h;

DOI:10.1016/j.tetlet.2019.151360

upstream raw materials:

4-hydroxyphenylpropionic acid

benzyl bromide

3-(4-hydroxyphenyl)propionic acid methyl ester

benzyl chloride

Downstream raw materials:

3-<4-(benzyloxy)phenyl>-propanoyl chloride

4-Benzyloxy-3'-oxodecylbenzene

methyl 3-(4-benzyloxyphenyl)propanoate

C₂₆H₂₅ClO₃

Refernces

• 1、 Mangum, Cathy L.,Munford, Mica B.,Sam, Alyssa B.,Young, Sandra K.,Beales, Jeremy T.,Subedi, Yagya Prasad,Mangum, Chad D.,Allen, Tanner J.,Liddell, Miranda S.,Merrell, Andrew I.,Saavedra, Diana I.,Williams, Becky L.,Evans, Nicole,Beales, Joseph L.,Christiansen, Michael A.. "The total syntheses of JBIR-94 and two synthetic analogs and their cytotoxicities against A549 (CCL-185) human small lung cancer cells". supporting information. . Retrieved 2019/11/29.
• 2、 -. "POLYMERIZABLE CHIRAL COMPOUND". Paragraph 0185; 0186. . Retrieved 2016/10/10.