METHYL 3-(4-(BENZYLOXY)PHENYL)PROPANOATE

Base Information

• Chemical Name: METHYL 3-(4-(BENZYLOXY)PHENYL)PROPANOATE
• CAS No.: 24807-40-7
• Molecular Formula: C17H18O3
• Molecular Weight: 270.328
• Hs Code.: 2918990090
• Mol file: 24807-40-7.mol

Synonyms:3-(4-(benzyloxy)-phenyl)propanoic acid methyl ester;Methyl 3-[4-(benzyloxy)phenyl]propanoate;3-(4-Benzyloxy-phenyl)-propionsaeure-methylester;3-(4-benzyloxyphenyl)propionic acid methyl ester;4-(benzyloxy)hydrocinnamic acid methyl ester;Propanoic acid,3-(4-benzyloxyphenyl)-,methyl ester;methyl-3-[4-(benzyloxy)phenyl]propionate;

Chemical Property of METHYL 3-(4-(BENZYLOXY)PHENYL)PROPANOATE

Chemical Property:

• PSA: 35.53000
• LogP: 3.37120
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

Methyl3-(4-(benzyloxy)phenyl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 3-(4-(BENZYLOXY)PHENYL)PROPANOATE

There total 22 articles about METHYL 3-(4-(BENZYLOXY)PHENYL)PROPANOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-methyl 3-(4-(benzyloxy)phenyl)acrylate (84184-51-0) → methyl 3-(4-benzyloxyphenyl)propanoate (24807-40-7)

Guidance literature:

With [2,2]bipyridinyl; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(98)01514-7

Reference yield: 95.0%

methanol (67-56-1) + 3-(4-benzyloxyphenyl)propanoic acid (50463-48-4) → methyl 3-(4-benzyloxyphenyl)propanoate (24807-40-7)

Guidance literature:

With diazomethyl-trimethyl-silane; at 25 ℃; for 16h;

Reference yield: 92.0%

3-(4-hydroxyphenyl)propionic acid methyl ester (5597-50-2) + benzyl chloride (100-44-7) → methyl 3-(4-benzyloxyphenyl)propanoate (24807-40-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 18h;

DOI:10.1016/j.tet.2005.05.055

upstream raw materials:

3-(4-hydroxyphenyl)propionic acid methyl ester

benzyl chloride

benzyl bromide

2-(4-Benzyloxyphenyl)-1,1-dibromoethylene

Downstream raw materials:

salidroside

3-(4-benzyloxyphenyl)-N-methoxy-N-methyl-propionamide

Refernces

• 1、 Sajiki, Hironao,Kuno, Hiroko,Hirota, Kosaku. "Suppression effect of the Pd/C-catalyzed hydrogenolysis of a phenolic benzyl protective group by the addition of nitrogen-containing bases". . p. 7127 - 7130. Retrieved 1998.
• 2、 Chiummiento, Lucia,Choppin, Sabine,Colobert, Fran?oise,Hanquet, Gilles,Massé, Paul. "Unintended Formation of a 26-Membered Cycle in the Course of a Novel Approach to Myricanol, a Strained [7,0]-Metacyclophane". supporting information. p. 559 - 564. Retrieved 2020/03/27.