(2R)-2-<4-(2-Methylpropyl)phenyl>propanal

Base Information

• Chemical Name: (2R)-2-<4-(2-Methylpropyl)phenyl>propanal
• CAS No.: 114937-27-8
• Molecular Formula: C₁₃H₁₈O
• Molecular Weight: 190.285
• Mol file: 114937-27-8.mol

Synonyms:(2R)-2-<4-(2-Methylpropyl)phenyl>propanal

Chemical Property of (2R)-2-<4-(2-Methylpropyl)phenyl>propanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-<4-(2-Methylpropyl)phenyl>propanal

There total 14 articles about (2R)-2-<4-(2-Methylpropyl)phenyl>propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-isobutyl-4-[(S)-1-methylallyl]benzene (85711-17-7) → (2R)-2-<4-(2-Methylpropyl)phenyl>propanal (114937-27-8)

Guidance literature:

1-isobutyl-4-[(S)-1-methylallyl]benzene; With ozone; In methanol; dichloromethane; at -78 ℃; for 0.5h;

With dimethylsulfide; In methanol; dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.tet.2005.03.120

Reference yield: 12.0%

carbon monoxide (201230-82-2) + p-isobutylstyrene (63444-56-4) → S-2-(p-isobutylphenyl)propionaldehyde (110773-62-1) + (2R)-2-<4-(2-Methylpropyl)phenyl>propanal (114937-27-8) + 3-(4-i-butyl-phenyl)-propanal (40764-03-2)

Guidance literature:

With acetylacetonatodicarbonylrhodium(l); hydrogen; (R,S)-binaphos; In benzene; at 60 ℃; for 66h; under 38000 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/ja970049d

Reference yield:

carbon monoxide (201230-82-2) + p-isobutylstyrene (63444-56-4) → (2R)-2-<4-(2-Methylpropyl)phenyl>propanal (114937-27-8) + 3-(4-i-butyl-phenyl)-propanal (40764-03-2)

Guidance literature:

With hydrogen; acetylacetonatodicarbonylrhodium(l); (R,S)-Ph₂P-binaphthyl-cyclic binaphthylphosphoramidite; In benzene; at 60 ℃; for 24h; under 15200 Torr;

DOI:10.1021/ja057065s

upstream raw materials:

carbon monoxide

p-isobutylstyrene

(2R)-2-<4-(2-methylpropyl)phenyl>propan-1-ol

1-isobutyl-4-[(S)-1-methylallyl]benzene

Downstream raw materials:

(4R)-2-<(1R)-1-(4-(2-Methylpropyl)phenyl)ethyl>thiazolidine-4-carboxylic Acid

(R)-ibuprofene

(2R)-2-<4-(2-methylpropyl)phenyl>propan-1-ol

Refernces

• 1、 Morimoto, Tsumoru,Fujii, Tetsuji,Miyoshi, Kota,Makado, Gouki,Tanimoto, Hiroki,Nishiyama, Yasuhiro,Kakiuchi, Kiyomi. "Accessible protocol for asymmetric hydroformylation of vinylarenes using formaldehyde". supporting information. p. 4632 - 4636. Retrieved 2015/04/27.
• 2、 Yan, Yongjun,Zhang, Xumu. "A hybrid phosphorus ligand for highly enantioselective asymmetric hydroformylation". . p. 7198 - 7202. Retrieved 2007/10/03.