4-Chloropyridine-2-carbonyl Chloride Hydrochloride

Base Information

• Chemical Name: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride
• CAS No.: 51727-15-2
• Molecular Formula: C6H4Cl3NO
• Molecular Weight: 0
• Mol file: 51727-15-2.mol

Synonyms:4-Chloro-2-pyridinecarbonyl Chloride Hydrochlorid;(4-Chloro-2-pyridinecarbonyl Chloride Hydrochloride)

Chemical Property of 4-Chloropyridine-2-carbonyl Chloride Hydrochloride

Chemical Property:

• Melting Point: 135-137°C (dec.)
• PSA: 29.96000
• LogP: 2.91600
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere

Purity/Quality:

99% ^*data from raw suppliers

4-Chloropyridine-2-carbonylChlorideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloropyridine-2-carbonyl Chloride Hydrochloride (cas# 51727-15-2) is a compound useful in organic synthesis.

Technology Process of 4-Chloropyridine-2-carbonyl Chloride Hydrochloride

There total 1 articles about 4-Chloropyridine-2-carbonyl Chloride Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Picolinic acid (98-98-6) → 4-chloro-2-pyridine carboxylic acid chloride hydrochloride (51727-15-2) + 2-picolinoyl chloride hydrochloride (39901-94-5)

Guidance literature:

With thionyl chloride; In N,N-dimethyl-formamide;

DOI:10.1080/00397911.2018.1564832

Reference yield: 94.0%

4-chloro-2-pyridine carboxylic acid chloride hydrochloride (51727-15-2) + dimethyl amine (124-40-3) → 4-chloro-N,N-dimethylpyridine-2-carboxamide (114780-06-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 5h; Inert atmosphere;

Reference yield: 90.0%

4-chloropicolinoyl chloride hydrochloride (51727-15-2) + isopropylamine (75-31-0) → N-isopropyl-4-chloro-2-pyridinecarboxamide (604813-08-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 2h;

upstream raw materials:

2-Picolinic acid

Downstream raw materials:

ethyl 4-chloropyridine-2-carboxylate

4-chloropicolinamide

N-isopropyl-4-chloro-2-pyridinecarboxamide

N-cyclopropyl-4-chloro-2-pyridinecarboxamide

Refernces