2H-Pyran-2-one, 6-acetyltetrahydro- (9CI)

Base Information

• Chemical Name: 2H-Pyran-2-one, 6-acetyltetrahydro- (9CI)
• CAS No.: 486405-21-4
• Molecular Formula: C7H10O3
• Molecular Weight: 142.1525
• Mol file: 486405-21-4.mol

Synonyms:2H-Pyran-2-one, 6-acetyltetrahydro- (9CI)

Chemical Property of 2H-Pyran-2-one, 6-acetyltetrahydro- (9CI)

Chemical Property:

• PSA: 43.37000
• LogP: 0.67110

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2H-Pyran-2-one, 6-acetyltetrahydro- (9CI)

There total 4 articles about 2H-Pyran-2-one, 6-acetyltetrahydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-acetyl-2-hydroxycyclopentanone (1262892-77-2) → 2-acetoxycyclopentanone (52789-75-0) + 6-acetyltetrahydro-2H-pyran-2-one (486405-21-4)

Guidance literature:

With potassium cyanide; In toluene; at 111 ℃; for 16h;

DOI:10.1021/acs.orglett.0c04157

Reference yield: 68.0%

hepta-5,6-dienoic acid (222167-25-1) → 6-acetyltetrahydro-2H-pyran-2-one (486405-21-4)

Guidance literature:

With 3,3-dimethyldioxirane; potassium carbonate; In acetone;

DOI:10.1016/S0040-4020(02)00698-1

Reference yield: 52.0%

1-(6-hydroxytetrahydropyran-2-yl)ethanone (947382-04-9) → 6-acetyltetrahydro-2H-pyran-2-one (486405-21-4)

Guidance literature:

With Celite; silver carbonate; In benzene; for 1h; Heating;

DOI:10.1002/chem.200601341

upstream raw materials:

hepta-5,6-dienoic acid

1-(6-hydroxytetrahydropyran-2-yl)ethanone

2-acetyl-2-hydroxycyclopentanone

2-acetylcyclopentanaone

Downstream raw materials:

6-Cyano-5-(3,5-dimethylbenzyl)-3,4-dihydro-2H-pyrano[2,3-b]pyridin-7-yl acetate

Refernces

• 1、 Fujioka, Hiromichi,Matsuda, Satoshi,Horai, Mai,Fujii, Eri,Morishita, Maiko,Nishiguchi, Natsuko,Hata, Kayoko,Kita, Yasuyuki. "Facile and efficient synthesis of lactols by a domino reaction of 2,3-epoxy alcohols with a hypervalent iodine(III) reagent and its application to the synthesis of lactones and the asymmetric synthesis of (+)-tanikolide". . p. 5238 - 5248. Retrieved 2008/02/10.