ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate

Base Information

• Chemical Name: ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate
• CAS No.: 321565-78-0
• Molecular Formula: C₁₂H₁₅ClO₄S
• Molecular Weight: 290.768
• Mol file: 321565-78-0.mol

Synonyms:ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate

Chemical Property of ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate

There total 1 articles about ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-methyl-2-phenylpropionate (2901-13-5) → ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate (321565-78-0)

Guidance literature:

With chlorosulfonic acid; In dichloromethane; at 20 ℃; for 22h;

DOI:10.1021/jm000538f

Reference yield:

ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate (321565-78-0) → ethyl 2-methyl-2-(4-sulfamoylphenyl)propionate (374067-94-4)

Guidance literature:

With ammonium hydroxide; In ethyl acetate; at 20 ℃; for 2h;

DOI:10.1021/jm000538f

Reference yield:

ethyl 2-(4-chlorosulfonylphenyl)-2-methylpropionate (321565-78-0) → N-(6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-5-(4-methylphenyl)-4-pyrimidinyl)-4-(1,1-dimethyl-2-((tetrahydro-2H-pyran-2-yl)oxy)ethyl)benzenesulfonamide (245118-91-6)

Guidance literature:

Multi-step reaction with 7 steps

1: 1.56 g / aq. NH₄OH / ethyl acetate / 2 h / 20 °C

2: 94 percent / aq. NaOH / methanol / 22 h / 20 °C

3: 98 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 3 h / 20 °C

4: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

5: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

6: NaH / 48 h / 110 °C

7: 395 mg / NaH / N,N-dimethyl-acetamide; tetrahydrofuran / 3 h / 20 °C

With ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; dimethyl sulfoxide; ethyl acetate;

DOI:10.1021/jm000538f

upstream raw materials:

ethyl 2-methyl-2-phenylpropionate

Downstream raw materials:

ethyl 2-methyl-2-(4-sulfamoylphenyl)propionate

4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide

2-methyl-2-(4-sulfamoylphenyl)propionic acid

N-(6-chloro-5-(4-methylphenyl)-4-pyrimidinyl)-4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide

Refernces