C₂₁H₁₅Cl₂F₂NO₃

Base Information

• Chemical Name: C₂₁H₁₅Cl₂F₂NO₃
• CAS No.: 1440063-32-0
• Molecular Formula: C₂₁H₁₅Cl₂F₂NO₃
• Molecular Weight: 438.258
• Mol file: 1440063-32-0.mol

Synonyms:C₂₁H₁₅Cl₂F₂NO₃

Chemical Property of C₂₁H₁₅Cl₂F₂NO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₁₅Cl₂F₂NO₃

There total 4 articles about C₂₁H₁₅Cl₂F₂NO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4'-Dichlorobiphenyl ether (6842-62-2) → C21H15Cl2F2NO3 (1440063-32-0)

Guidance literature:

Multi-step reaction with 4 steps

1: aluminum (III) chloride / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride / ethanol / 5 h / Reflux; Inert atmosphere

3: sodium tetrahydroborate; iodine / tetrahydrofuran / 7.5 h / 0 °C / Reflux; Inert atmosphere

4: triethylamine / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; hydroxylamine hydrochloride; iodine; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; 1: |Friedel-Crafts Acylation;

DOI:10.1039/c3nj00032j

Reference yield:

C14H13Cl2NO2 (1440062-60-1) + 2,6-difluorobenzoylchloride (18063-02-0) → C21H15Cl2F2NO3 (1440063-32-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 5 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3nj00032j

Reference yield:

C16H13Cl2NO4 (1440061-93-7) → C21H15Cl2F2NO3 (1440063-32-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrahydroborate; iodine / tetrahydrofuran / 7.5 h / 0 °C / Reflux; Inert atmosphere

2: triethylamine / tetrahydrofuran / 2 h / 5 - 20 °C / Inert atmosphere

With sodium tetrahydroborate; iodine; triethylamine; In tetrahydrofuran;

DOI:10.1039/c3nj00032j

upstream raw materials:

C₁₆H₁₃Cl₂NO₄

C₁₆H₁₂Cl₂O₄

3,4'-Dichlorobiphenyl ether

C₁₄H₁₃Cl₂NO₂

Downstream raw materials:

4-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-(2,6-difluorophenyl)-1,3-oxazoline

C₂₁H₁₄Cl₃F₂NO₂

Refernces