2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene

Base Information

• Chemical Name: 2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene
• CAS No.: 222557-94-0
• Molecular Formula: C₂₀H₂₁N₃O₈S
• Molecular Weight: 463.468
• Mol file: 222557-94-0.mol

Synonyms:2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene

Chemical Property of 2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene

There total 5 articles about 2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2-Methyl-3,5-dinitrothiophene (78771-28-5) + 4-(bis(2-acetoxyethyl)amino)benzaldehyde (41313-77-3) → 2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene (222557-94-0)

Guidance literature:

With pyrrolidine; In tetrahydrofuran; for 20h; Heating;

DOI:10.1039/a904945b

Reference yield:

2-Methylthiophene (554-14-3) → 2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene (222557-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 32 percent / HNO₃; Ac₂O / -10 - -5 °C

2: 76 percent / HNO₃; H₂SO₄ / 0.5 h / 5 - 10 °C

3: 56 percent / pyrrolidine / tetrahydrofuran / 20 h / Heating

With pyrrolidine; sulfuric acid; nitric acid; acetic anhydride; In tetrahydrofuran; 1: Nitration / 2: Nitration / 3: Condensation;

DOI:10.1039/a904945b

Reference yield:

5-nitro-2-methylthiophene (42297-94-9) → 2-{[4-Bis(acetoxyethyl)phenyl]ethenyl}-3,5-dinitrothiophene (222557-94-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / HNO₃; H₂SO₄ / 0.5 h / 5 - 10 °C

2: 56 percent / pyrrolidine / tetrahydrofuran / 20 h / Heating

With pyrrolidine; sulfuric acid; nitric acid; In tetrahydrofuran; 1: Nitration / 2: Condensation;

DOI:10.1039/a904945b

upstream raw materials:

2-Methyl-3,5-dinitrothiophene

4-(bis(2-acetoxyethyl)amino)benzaldehyde

2-Methylthiophene

5-nitro-2-methylthiophene

Refernces