Technology Process of (7aR,1R)-4-(2-benzyloxyethyl)-7a-methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-inden-1-ol, pivaloate ester
There total 3 articles about (7aR,1R)-4-(2-benzyloxyethyl)-7a-methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-inden-1-ol, pivaloate ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(7aR,1R)-7a-methyl-5-oxo-2,3,5,6,7,7a-hexahydro-1H-inden-1-ol, pivaloate ester;
With
sodium methylsulfinylmethanide;
In
tetrahydrofuran; dimethyl sulfoxide;
at -78 - 20 ℃;
benzyl iodoethyl ether;
In
tetrahydrofuran; dimethyl sulfoxide;
at 20 ℃;
for 6h;
Further stages.;
DOI:10.1021/ol015763l
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 37.8 g / 4-dimethylaminopyridine / pyridine / 17 h / 20 °C
2.1: NaCH2SOCH3 / dimethylsulfoxide; tetrahydrofuran / -78 - 20 °C
2.2: 61 percent / tetrahydrofuran; dimethylsulfoxide / 6 h / 20 °C
With
dmap; sodium methylsulfinylmethanide;
In
tetrahydrofuran; pyridine; dimethyl sulfoxide;
DOI:10.1021/ol015763l
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: NaBH4 / ethanol / -78 - 5 °C
2.1: 37.8 g / 4-dimethylaminopyridine / pyridine / 17 h / 20 °C
3.1: NaCH2SOCH3 / dimethylsulfoxide; tetrahydrofuran / -78 - 20 °C
3.2: 61 percent / tetrahydrofuran; dimethylsulfoxide / 6 h / 20 °C
With
dmap; sodium tetrahydroborate; sodium methylsulfinylmethanide;
In
tetrahydrofuran; pyridine; ethanol; dimethyl sulfoxide;
DOI:10.1021/ol015763l