1-BENZYLOXY-2-IODOETHANE

Base Information

• Chemical Name: 1-BENZYLOXY-2-IODOETHANE
• CAS No.: 54555-84-9
• Molecular Formula: C9H11IO
• Molecular Weight: 262.09
• Hs Code.: 2909309090
• European Community (EC) Number: 632-600-9
• DSSTox Substance ID: DTXSID10438638
• Nikkaji Number: J1.190.815B
• Wikidata: Q82254444
• Mol file: 54555-84-9.mol

Synonyms:1-BENZYLOXY-2-IODOETHANE

Chemical Property of 1-BENZYLOXY-2-IODOETHANE

Chemical Property:

• Refractive Index: n20/D1.578
• Boiling Point: 83-87 °C(Press: 0.5 Torr)
• PSA: 9.23000
• Density: 1.598±0.06 g/cm3(Predicted)
• LogP: 2.63820
• Sensitive.: Light Sensitive
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 261.98546
• Heavy Atom Count: 11
• Complexity: 89.6

Purity/Quality:

99% ^*data from raw suppliers

1-BENZYLOXY-2-IODOETHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COCCI

Technology Process of 1-BENZYLOXY-2-IODOETHANE

There total 14 articles about 1-BENZYLOXY-2-IODOETHANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

bromoethyl-2-benzyl ether (1462-37-9) → benzyl iodoethyl ether (54555-84-9)

Guidance literature:

With sodium iodide; In acetone; Reflux;

DOI:10.1002/anie.201807097

Reference yield: 88.0%

(benzyloxy)ethyl 4-bromobenzenesulfonate → benzyl iodoethyl ether (54555-84-9)

Guidance literature:

With sodium iodide; In dichloromethane; acetone;

Reference yield: 87.0%

Iodoethanol (624-76-0) + O-benzyl 2,2,2-trichloroacetimidate (81927-55-1) → benzyl iodoethyl ether (54555-84-9) + trichloroacetamide (594-65-0)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; cyclohexane; for 18h; Ambient temperature;

DOI:10.1021/jm00111a026

upstream raw materials:

benzyl 2-chloroethyl ether

Iodoethanol

O-benzyl 2,2,2-trichloroacetimidate

benzyl bromide

Downstream raw materials:

4-Benzyloxy-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-butyric acid ethyl ester

7-(1-Benzenesulfonyl-1H-indol-2-yl)-8-(2-benzyloxy-ethyl)-1,4-dioxa-8-aza-spiro[4.5]decane

(2R,3S)-2-(2-Benzyloxy-ethyl)-3-hydroxy-2-methyl-succinic acid diethyl ester

diethyl (2R,3S)-3-(2-benzyloxyethyl)malate

Refernces

• 1、 Rocaboy, Ronan,Dailler, David,Zellweger, Florian,Neuburger, Markus,Salomé, Christophe,Clot, Eric,Baudoin, Olivier. "Domino Pd0-Catalyzed C(sp3)–H Arylation/Electrocyclic Reactions via Benzazetidine Intermediates". supporting information. p. 12131 - 12135. Retrieved 2018/09/11.
• 2、 Shen, Peng-Xiang,Wang, Xiao-Chen,Wang, Peng,Zhu, Ru-Yi,Yu, Jin-Quan. "Ligand-Enabled Meta-C-H Alkylation and Arylation Using a Modified Norbornene". supporting information. p. 11574 - 11577. Retrieved 2015/09/28.