tetrahydro-2H-pyran-3-amine

Base Information

• Chemical Name: tetrahydro-2H-pyran-3-amine
• CAS No.: 120811-32-7
• Molecular Formula: C5H11NO
• Molecular Weight: 101.148
• Hs Code.: 2932999099
• European Community (EC) Number: 675-842-0
• DSSTox Substance ID: DTXSID70409440
• Mol file: 120811-32-7.mol

Synonyms:tetrahydro-2H-pyran-3-amine;120811-32-7;oxan-3-amine;Tetrahydro-pyran-3-ylamine;2H-PYRAN-3-AMINE, TETRAHYDRO-;Tetrahydropyran-3-ylamine;MFCD07371531;tetrahydropyran-3-amine;2H-Pyran-3-amine,tetrahydro-;(S)-3-Aminotetrahydropyran;MFCD11053730;3-aminotetrahydropyran;3-Aminotetrahydropyran HCl;(R)-3-Aminotetrahydropyran;3-Amino-1H-tetrahydropyran;tetrahydro-pyran-3-yl amine;SCHEMBL57654;DTXSID70409440;WUUOEJJGRCQGBQ-UHFFFAOYSA-N;MFCD11053731;AKOS000321356;AKOS016341066;TETRAHYDRO-2H-PYRAN-3-YLAMINE;PB30901;SB13305;SB13307;SB20074;AS-46772;SY003103;SY008242;SY008243;Tetrahydro-2H-pyran-3-amine, AldrichCPR;AM20080156;BB 0219939;CS-0044162;FT-0660171;FT-0772782;FT-0773181;1-aminoCyclopropanecarboxylic acid ethyl ester;EN300-70458;(S)-Tetrahydro-2H-pyran-3-amine?hydrochloride;A18127;F10442;J-502292;J-502549;Tetrahydro-2H-pyran-3-amine;Tetrahydropyran-3-amine;W-205100;Z1013492300

Chemical Property of tetrahydro-2H-pyran-3-amine

Chemical Property:

• Vapor Pressure: 3.68mmHg at 25°C
• Refractive Index: 1.449
• Boiling Point: 151.357 °C at 760 mmHg
• PKA: 9.97±0.20(Predicted)
• Flash Point: 49.266 °C
• PSA: 35.25000
• Density: 0.963 g/cm³
• LogP: 0.82440
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 101.084063974
• Heavy Atom Count: 7
• Complexity: 56

Purity/Quality:

98%,99%, ^*data from raw suppliers

Tetrahydro-2H-pyran-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC(COC1)N

Technology Process of tetrahydro-2H-pyran-3-amine

There total 1 articles about tetrahydro-2H-pyran-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → (+/-)-3-aminotetrahydropyran (120811-32-7)

Guidance literature:

With 3,6‐di‐tert‐butyl‐9‐mesityl‐10‐phenylacridin‐10‐ium tetrafluoroborate; ammonium carbonate; 2-amino-benzenethiol; In dichloromethane; acetonitrile; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202016679

Reference yield: 65.0%

(+/-)-3-aminotetrahydropyran (120811-32-7) + 1-[4-(i-propyl)phenyl]-pentane-1,4-dione (1033280-93-1) → 2-(4-isopropylphenyl)-5-methyl-1-(tetrahydro-2H-pyran-3-yl)-1H-pyrrole

Guidance literature:

With toluene-4-sulfonic acid; In ethanol; at 160 ℃; for 0.5h; under 7757.43 Torr; Sealed tube; Microwave irradiation;

DOI:10.1016/j.ejmech.2017.12.075

Reference yield:

(+/-)-3-aminotetrahydropyran (120811-32-7) + carbon monoxide (201230-82-2) + 1-(4-(1H-pyrazol-1-yl)benzyl)-3-iodo-1H-pyrrolo[3,2-b]pyridine → 1-(4-(1H-pyrazol-1-yl)benzyl)-N-(tetrahydro-2H-pyran-3-yl)-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

Guidance literature:

With palladium diacetate; sodium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃;

upstream raw materials:

3,4-dihydro-2H-pyran

Downstream raw materials:

C₁₈H₁₈N₄O₅S

N-(tetrahydropyran-3-yl)benzene-1,2-diamine

Refernces