Technology Process of SR 3850
There total 8 articles about SR 3850 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium hydride / mineral oil; tetrahydrofuran / 0 - 20 °C
2: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 100 °C / Alkaline conditions; Inert atmosphere
3: tin(ll) chloride / ethyl acetate / 20 °C
4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C
With
tetrakis(triphenylphosphine) palladium(0); sodium hydride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; tin(ll) chloride;
In
tetrahydrofuran; 1,4-dioxane; water; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
2: |Suzuki Coupling;
DOI:10.1016/j.bmc.2019.02.047
- Guidance literature:
-
With
N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
N,N-dimethyl-formamide;
at 20 ℃;
DOI:10.1016/j.bmc.2019.02.047
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
ethanol; water; toluene;
at 140 ℃;
for 1h;
Microwave irradiation;
DOI:10.1016/j.bmcl.2008.10.080
