269410-08-4 Usage
Description
Pyrazole-4-boronic acid pinacol ester is an organic compound that serves as a versatile reagent in the synthesis of various biologically active compounds and inhibitors. It is characterized by its off-white to tan powder appearance and plays a significant role in the pharmaceutical and chemical industries due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
Pyrazole-4-boronic acid pinacol ester is used as a key intermediate for the preparation of Rho kinase (ROCK) inhibitors and other biologically active compounds. It is crucial in the development of drugs targeting various therapeutic enzymes and kinases, which are essential for treating numerous diseases and conditions.
Used in Chemical Synthesis:
Pyrazole-4-boronic acid pinacol ester is used as a valuable reagent for Suzuki-Miyaura cross-couplings and Ruthenium-catalyzed asymmetric hydrogenation. These reactions are vital in the synthesis of complex organic molecules and contribute to the advancement of chemical research and development.
Used in the Preparation of Inhibitors:
Pyrazole-4-boronic acid pinacol ester is employed as a reagent in the preparation of inhibitors for many highly significant therapeutic enzymes and kinases, including VEGF, Aurora, Rho (ROCK), Janus Kinase 2 (JAK), c-MET, ALK, S-nitrosoglutathione reductase, CDC7, Acetyl-CoA carboxylase, Prosurvival Bcl-2 protein, Viral RNA-Dependent RNA polymerase, Long Chain Fatty Acid Elongase, 6PI3, AKT, Chk1, and Protein Kinase B. These inhibitors play a crucial role in the development of targeted therapies for various diseases, including cancer and other conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 269410-08-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,9,4,1 and 0 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 269410-08:
(8*2)+(7*6)+(6*9)+(5*4)+(4*1)+(3*0)+(2*0)+(1*8)=144
144 % 10 = 4
So 269410-08-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)
269410-08-4Relevant articles and documents
Efficient salt-induced kinase inhibitor and preparation method thereof
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Paragraph 0041; 0054; 0055, (2021/09/04)
The invention discloses an efficient salt-induced kinase inhibitor and a preparation method thereof, and the efficient salt-induced kinase inhibitor is characterized by comprising substances of a chemical formula in the invention. The salt-induced kinase inhibitor with excellent performance has high inhibitory activity for in-vitro experiments and also has high cell inhibitory activity.
PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE
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Paragraph 0781-0782, (2021/09/26)
The present invention provides, in part, novel small molecule inhibitors of PHD, having a structure according to Formula (A), and sub-formulas thereof: or a pharmaceutically acceptable salt thereof. The compounds provided herein can be useful for treatment of diseases including heart ( e.g. ischemic heart disease, congestive heart failure, and valvular heart disease), lung (e.g., acute lung injury, pulmonary hypertension, pulmonary fibrosis, and chronic obstructive pulmonary disease), liver (e.g. acute liver failure and liver fibrosis and cirrhosis), and kidney (e.g. acute kidney injury and chronic kidney disease) disease.
Synthesis method of pyrazole-4-pinacolato diboron
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, (2020/02/14)
The invention discloses a synthesis method of pyrazole-4-pinacolato diboron. According to the method, trimethylbenzene is added as a stable solvent during reaction, so that side reaction in the reaction process is reduced, the method is simple to operate, low in cost and easy to purify and amplify industrial production, and the technical problems that synthesis and purification of pyrazole-4-pinacolato diboron are difficult at present and the like are solved.