847818-71-7

Basic information

• Product Name: 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
• Synonyms: 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-(2-Methoxyethyl)-1H-pyrazole-4-boronic acid, pinacol ester;1-(2-Methoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, Methyl 2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]ethyl ether;1-(2-Methoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, 2-[1-(2-Methoxyethyl)-1H-pyrazol-4-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;Pinacol 1-(2-methoxyethyl)-4-pyrazolyl-boronate;(1-(2-METHOXYETHYL)-1H-PYRAZOL-4-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 847818-71-7
• Molecular Formula: C₁₂H₂₁BN₂O₃
• Molecular Weight: 252.11774
• Mol File: 847818-71-7.mol
• Article Data: 32

Chemical Properties

• Melting Point: 54 °C
• Boiling Point: 356.4°C at 760 mmHg
• Flash Point: 169.4°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 6E-05mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 1.87±0.10(Predicted)
• CAS DataBase Reference: 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(847818-71-7)
• EPA Substance Registry System: 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole(847818-71-7)

Safety Data

• Hazardous Substances Data: 847818-71-7(Hazardous Substances Data)

Usage

General Description

1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is a chemical compound with the molecular formula C12H20BNO2. It is a pyrazole derivative containing a boron atom and a methoxyethyl group. 1-(2-Methoxyethyl)-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is commonly used as a building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. The boron atom in the molecule makes it a valuable reagent in Suzuki-Miyaura cross-coupling reactions, allowing for the formation of carbon-carbon bonds. Additionally, the pyrazole moiety in the compound gives it potential biological activity, making it a subject of interest in medicinal chemistry research.

InChI:InChI=1/C12H21BN2O3/c1-11(2)12(3,4)18-13(17-11)10-8-14-15(9-10)6-7-16-5/h8-9H,6-7H2,1-5H3

Upstream product

• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 847818-59-1 1-(2-methoxyethyl)-1H-pyrazol-4-ylboronic acid 
• 61676-62-8 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1407429-97-3 4-iodo-1-(2-methoxyethyl)-1H-pyrazole 
• 73183-34-3 bis(pinacol)diborane 
• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 627-42-9 2-chloroethyl methyl ether 
• 6482-24-2 2-Bromoethyl methyl ether 
• 847818-49-9 4-bromo-1-(2-methoxyethyl)-1H-pyrazole 

Downstream Products

• 1040376-75-7 3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-[1-(2-methoxy-ethyl)-1H-pyrazol-4-yl]-2-methyl-pyridine 
• 1352152-58-9 (S)-tert-butyl 1-(1-amino-3-(4-(1-(2-methoxyethyl)-1H-pyrazol-4-yl)phenyl)-1-oxopropan-2-ylcarbamoyl)cyclohexylcarbamate 
• 1257994-16-3 diethyl (4-{[4-({7-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzyl)phosphonate 

Relevant articles and documents

AMINOPYRIDINE COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF

The present invention discloses an aminopyridine compounds, a preparation method and use thereof, particularly the aminopyridine compounds of formula (I), pharmaceutical compositions containing the same, the method for preparing the same and the use thereof in the prophylaxis or treatment of an adenosine A2a receptor related disease.

MAP4K4 INHIBITORS

This invention relates to compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these compounds, for example in a method of treatmentof cardiac conditions.In particular, the present invention relates to compounds of formula (I):

Structure-based design and synthesis of 1H-pyrazolo[3,4-d]pyrimidin-4-amino derivatives as Janus kinase 3 inhibitors

Janus kinases (JAKs) regulate various inflammatory and immune responses and are targets for the treatment of inflammatory and immune diseases. Here we report the discovery and optimization of 1H-pyrazolo[3,4-d]pyrimidin-4-amino as covalent JAK3 inhibitors that exploit a unique cysteine (Cys909) residue in JAK3. Our optimization study gave compound 12a, which exhibited potent JAK3 inhibitory activity (IC50 of 6.2 nM) as well as excellent JAK kinase selectivity (>60-fold). In cellular assay, 12a exhibited potent immunomodulating effect on IL-2-stimulated T cell proliferation (IC50 of 9.4 μM). Further, compound 12a showed efficacy in delayed hypersensitivity assay. The data supports the further investigation of these compounds as novel JAKs inhibitors.