1072906-08-1

Basic information

• Product Name: N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)acetamide
• Synonyms: N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)acetamide
• CAS NO: 1072906-08-1
• Molecular Weight: 288.349
• Mol File: 1072906-08-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)acetamide(1072906-08-1)
• EPA Substance Registry System: N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)acetamide(1072906-08-1)

Safety Data

• Hazardous Substances Data: 1072906-08-1(Hazardous Substances Data)

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 

Relevant articles and documents

Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors

The identification of a new class of potent and selective ROCK-II inhibitors is presented. Compound 5 (SR-3677) had an IC50 of ～3 nM in enzyme and cell based assays and had an off-target hit rate of 1.4% against 353 kinases, and inhibited only 3 out of 70 nonkinase enzymes and receptors. Pharmacology studies showed that 5 was efficacious in both, increasing ex vivo aqueous humor outflow in porcine eyes and inhibiting myosin light chain phosphorylation.