(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

Base Information

• Chemical Name: (+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine
• CAS No.: 60929-58-0
• Molecular Formula: C₃₃H₃₁NO₃
• Molecular Weight: 489.614
• Mol file: 60929-58-0.mol

Synonyms:(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

Chemical Property of (+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

There total 5 articles about (+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

R,S-2-hydroxymethyl-4-benzylmorpholine (40987-24-4,943442-96-4) → (+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine (60929-58-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / H₂ / 10percent Pd-C / methanol / Ambient temperature

2: 96.4 percent / Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

3: 70 percent / pyridine / CH₂Cl₂ / 15 h / Ambient temperature

4: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.3766

Reference yield:

ethyl acetoacetate (141-97-9) + potassium salt of 1-oxo-4-indanol (65043-21-2) + 2-(p-toluenesulfonyloxymethyl)-4-triphenylmethylmorpholine (60929-57-9) → (+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine (60929-58-0)

Guidance literature:

With sodium hydroxide; In hexane; dimethyl sulfoxide;

Reference yield:

morpholin-2-ylmethanol (103003-01-6) → (+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine (60929-58-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 96.4 percent / Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

2: 70 percent / pyridine / CH₂Cl₂ / 15 h / Ambient temperature

3: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C

With pyridine; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.33.3766

upstream raw materials:

R,S-2-hydroxymethyl-4-benzylmorpholine

morpholin-2-ylmethanol

(+/)-2-hydroxymethyl-4-triphenylmethylmorpholine

ethyl acetoacetate

Downstream raw materials:

(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride

(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride

2-(7-indenyloxymethyl)-morpholine hydrochloride

(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

Refernces

• 1、 -. "2-(Indenyloxymethyl) morpholine derivatives". . . Retrieved 2008/06/13.