Indeloxazine hydrochloride

Base Information

• Chemical Name: Indeloxazine hydrochloride
• CAS No.: 65043-22-3
• Molecular Formula: C14H17 N O2 . Cl H
• Molecular Weight: 267.755
• Hs Code.: 2934999090
• UNII: 15QZ6NE84E
• DSSTox Substance ID: DTXSID60983582
• Wikidata: Q27251740
• NCI Thesaurus Code: C81478
• ChEMBL ID: CHEMBL2448146
• Mol file: 65043-22-3.mol

Synonyms:2-(7-indenyloxymethyl)morpholine;AS1069562;indeloxazine;indeloxazine hydrochloride;indeloxazine hydrochloride, (+)-isomer;indeloxazine, (+)-isomer;YM 08054-1;YM-08054-1

Chemical Property of Indeloxazine hydrochloride

Chemical Property:

• Vapor Pressure: 1.18E-06mmHg at 25°C
• Melting Point: 169-170°; mp 155-156°
• Boiling Point: 401.4°C at 760 mmHg
• Flash Point: 160.3°C
• PSA: 30.49000
• LogP: 2.75390
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 267.1026065
• Heavy Atom Count: 18
• Complexity: 279

Purity/Quality:

99%, ^*data from raw suppliers

2-(((1H-Inden-7-yl)oxy)methyl)morpholineHCl 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(CN1)COC2=CC=CC3=C2CC=C3.Cl
• Description: Indeloxazine hydrochloride is a nootropic indicated for the treatment of senile dementia. In animal models indeloxazine reportedly enhances brain energy metabolism and monoamine content; its claimed protective effect on ischemia-induced amnesia is supported by the prolonged step-through latency in passive avoidance tests.
• Uses: Antidepressant.

Technology Process of Indeloxazine hydrochloride

There total 25 articles about Indeloxazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.4%

(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine (64966-73-0) → 2-(7-indenyloxymethyl)-morpholine hydrochloride (65043-22-3)

Guidance literature:

With hydrogenchloride; In ethanol; for 17h; Heating;

DOI:10.1248/cpb.33.3766

Reference yield: 73.0%

sulfuric acid mono-(2-amino-ethyl ester) (926-39-6) + 1-(inden-7-yloxy)-2,3-epoxypropane (30190-85-3) → 2-(7-indenyloxymethyl)-morpholine hydrochloride (65043-22-3)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In methanol; 1.) 55 deg C, 16 h; 2.) iso-PrOH, acetone, 0-5 deg C, 15 min.;

DOI:10.1248/cpb.33.3766

Reference yield: 40.0%

→ 2-(7-indenyloxymethyl)-morpholine hydrochloride (65043-22-3)

Guidance literature:

upstream raw materials:

sulfuric acid mono-(2-amino-ethyl ester)

1-(inden-7-yloxy)-2,3-epoxypropane

(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

Downstream raw materials:

(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride

(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride

Refernces

• 1、 -. "2-(Indenyloxymethyl) morpholine derivatives". . . Retrieved 2008/06/13.