CAS No.65043-22-3,Indeloxazine hydrochloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	65043-22-3
Name:	Indeloxazine hydrochloride
Article Data:	2

Formula:	C14H17 N O2 . Cl H
Molecular Weight:	267.755
Synonyms:	Morpholine,2-[(1H-inden-7-yloxy)methyl]-, hydrochloride (9CI); CI 874; Elen; Indeloxazinehydrochloride; Noin; YM 08054; YM 08054-1
Melting Point:	169-170°; mp 155-156°
Boiling Point:	401.4°C at 760 mmHg
Flash Point:	160.3°C
Safety:	Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl.
PSA:	30.49000
LogP:	2.75390

Synthetic route

: 64966-73-0
(+/-)-2-<(1-hydoxyindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 17h; Heating;	73.4%

: 926-39-6
sulfuric acid mono-(2-amino-ethyl ester)

: 30190-85-3
1-(inden-7-yloxy)-2,3-epoxypropane

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium hydroxide In methanol 1.) 55 deg C, 16 h; 2.) iso-PrOH, acetone, 0-5 deg C, 15 min.;	73%

: 60929-58-0
(+/-)-2-<(1-oxoindan-4-yloxy)methyl>-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 2: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 40987-24-4
R,S-2-hydroxymethyl-4-benzylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: 95 percent / H2 / 10percent Pd-C / methanol / Ambient temperature 2: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature 3: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature 4: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 5: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 6: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

Yield

Multi-step reaction with 6 steps
1: 95 percent / H2 / 10percent Pd-C / methanol / Ambient temperature
2: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature
3: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature
4: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C
5: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature
6: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating
View Scheme

: 103003-01-6
morpholin-2-ylmethanol

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1: 96.4 percent / Et3N / CH2Cl2 / 10 h / Ambient temperature 2: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature 3: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 4: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 5: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 131965-77-0
(+/)-2-hydroxymethyl-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: 70 percent / pyridine / CH2Cl2 / 15 h / Ambient temperature 2: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 3: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 4: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 60929-57-9
2-(p-toluenesulfonyloxymethyl)-4-triphenylmethylmorpholine

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 73.5 percent / dimethylformamide / 17 h / 100 - 105 °C 2: 77.7 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature 3: 73.4 percent / 0.5 N HCl / ethanol / 17 h / Heating View Scheme

: 60929-60-4
4-morpholin-2-ylmethoxy-indan-1-ol

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride; sodium chloride In ethanol; chloroform; acetone

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

: 65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2
(+)-indeloxazine hydrochloride, (+)-YM-08054 hydrochloride

Conditions

Conditions	Yield
Yield given;

: 65043-22-3
2-(7-indenyloxymethyl)-morpholine hydrochloride

: 65043-22-3, 76489-35-5, 104908-10-3, 104908-43-2
(-)-indeloxazine hydrochloride; (-)-YM-08054 hydrochloride

Conditions

Conditions	Yield
Yield given;

Raw Materials

926-39-6

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Chemistry

Product Name: Indeloxazine hydrochloride
CAS Registry Number: 65043-22-3
IUPAC Name: 2-(3H-inden-4-yloxymethyl)morpholine hydrochloride
Molecular Weight: 267.75122 [g/mol]
Molecular Formula: C₁₄H₁₈ClNO₂
H-Bond Donor: 2
H-Bond Acceptor: 3
Flash Point: 160.3 °C
Enthalpy of Vaporization: 65.24 kJ/mol
Boiling Point: 401.4 °C at 760 mmHg
Vapour Pressure: 1.18E-06 mmHg at 25°C
Following is the molecular structure of Indeloxazine hydrochloride (CAS NO.65043-22-3) is:

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 60mg/kg (60mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
mouse	LD50	intraperitoneal	50400ug/kg (50.4mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 1181, 1988.
mouse	LD50	intravenous	47mg/kg (47mg/kg)	SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 238, Pg. 81, 1979.
mouse	LD50	oral	340mg/kg (340mg/kg)		United States Patent Document. Vol. #4297356,
mouse	LD50	subcutaneous	245mg/kg (245mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat	LD50	intravenous	77300ug/kg (77.3mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat	LD50	oral	502mg/kg (502mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985.
rat	LD50	subcutaneous	206mg/kg (206mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Kiso to Rinsho. Clinical Report. Vol. 19, Pg. 5687, 1985

Safety Profile

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NO_x and HCl.
RIDADR: 3249
HazardClass: 6.1(b)
PackingGroup: III

Specification

Indeloxazine hydrochloride , its cas register number is 65043-22-3. It also can be called Indeloxazine hydrochloride [USAN:JAN] ; (+-)-2-((Inden-7-yloxy)methyl)morpholine hydrochloride ; 2-((1H-Inden-7-yloxy)methyl)morpholine hydrochloride ; CI 874 ; Indeloxazine HCl ; Indeloxazine hydrochloride ; Morpholine, 2-((1H-inden-7-yloxy)methyl)-, hydrochloride, (+-)- ; UNII-15QZ6NE84E ; YM 08054-1 ; YM-08054-1 .