α-ethyl-3-nitrobenzyl alcohol

Base Information

• Chemical Name: α-ethyl-3-nitrobenzyl alcohol
• CAS No.: 29067-53-6
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.191
• Mol file: 29067-53-6.mol

Synonyms:α-ethyl-3-nitrobenzyl alcohol

Chemical Property of α-ethyl-3-nitrobenzyl alcohol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of α-ethyl-3-nitrobenzyl alcohol

There total 2 articles about α-ethyl-3-nitrobenzyl alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3'-nitropropiophenone (17408-16-1) → α-ethyl-3-nitrobenzyl alcohol (29067-53-6)

Guidance literature:

With chloro-trimethyl-silane; tert-Amyl alcohol; sodium hydride; zinc(II) chloride; In tetrahydrofuran; at 63 ℃; for 0.5h;

Reference yield:

1-phenyl-propan-1-one (93-55-0) → α-ethyl-3-nitrobenzyl alcohol (29067-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NO₂/HNO₃

2: NaBH₄ / methanol; H₂O

With sodium tetrahydroborate; nitric acid; Nitrogen dioxide; In methanol; water;

DOI:10.1021/ja00841a033

Reference yield: 16.0%

α-ethyl-3-nitrobenzyl alcohol (29067-53-6) + piperidine-4-carboxylic acid cyclohexylamide hydrochloride (1019851-98-9) → rac-1-[1-(3-nitro-phenyl)-propyl]-piperidine-4-carboxylic acid cyclohexylamide

Guidance literature:

α-ethyl-3-nitrobenzyl alcohol; With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20 ℃; for 2.5h;

piperidine-4-carboxylic acid cyclohexylamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 70 ℃;

upstream raw materials:

3'-nitropropiophenone

1-phenyl-propan-1-one

Downstream raw materials:

1-Bromo-1-(3-nitro-phenyl)-propan

(S)-1-(3-nitrophenyl)propan-1-ol

2-(3-nitrophenyl)butanenitrile

2-(3-nitro-phenyl)-butyric acid

Refernces

• 1、 Feghouli, Ghania,Vanderesse, Regis,Fort, Yves,Caubere, Paul. "Selective Reduction of the Carbonyl Group of Functional Nitroaromatic Derivatives: A New Application of Complex Reducing Agents ZnCRASi". . p. 849 - 854. Retrieved 2007/10/02.