Pyrido[1,2-a]benzimidazol-8-ol (9CI)

Base Information

• Chemical Name: Pyrido[1,2-a]benzimidazol-8-ol (9CI)
• CAS No.: 123444-29-1
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.197
• Mol file: 123444-29-1.mol

Synonyms:8-Hydroxypyrido[1,2-a]benzimidazole

Chemical Property of Pyrido[1,2-a]benzimidazol-8-ol (9CI)

Chemical Property:

• PSA: 37.53000
• LogP: 2.19310

Purity/Quality:

PYRIDO[1,2-A]BENZIMIDAZOL-8-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrido[1,2-a]benzimidazol-8-ol (9CI)

There total 6 articles about Pyrido[1,2-a]benzimidazol-8-ol (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

8-methoxybenzo[4,5]imidazo[1,2-a]pyridine (99261-89-9) → 8-hydroxypyrido[1,2-a]benzimidazole (123444-29-1)

Guidance literature:

With boron tribromide; In dichloromethane; at -20 - 25 ℃; for 6h;

Reference yield:

2-bromo-pyridine (109-04-6) → 8-hydroxypyrido[1,2-a]benzimidazole (123444-29-1)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium tert-butylate / toluene / 14 h / 110 °C / Inert atmosphere

2: 1,1,1,3',3',3'-hexafluoro-propanol; iodobenzene; 3-chloro-benzenecarboperoxoic acid / 2 h / 25 °C

3: boron tribromide / dichloromethane / 6 h / -20 - 25 °C

With iodobenzene; 1,1,1,3',3',3'-hexafluoro-propanol; potassium tert-butylate; palladium diacetate; boron tribromide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; toluene;

Reference yield:

N-(4-methoxyphenyl)pyridin-2-amine (78644-78-7) → 8-hydroxypyrido[1,2-a]benzimidazole (123444-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,1,1,3',3',3'-hexafluoro-propanol; iodobenzene; 3-chloro-benzenecarboperoxoic acid / 2 h / 25 °C

2: boron tribromide / dichloromethane / 6 h / -20 - 25 °C

With iodobenzene; 1,1,1,3',3',3'-hexafluoro-propanol; boron tribromide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

upstream raw materials:

2-aminopyridine

acetic acid

p-benzoquinone

2-bromo-pyridine

Refernces

• 1、 -. "Amine compound for inhibiting SSASASASASASASAO/VAP-1 and application thereof in medicine (by machine translation)". . . Retrieved 2019/08/12.