N-BOC-3-MESYLOXYPIPERIDINE

Base Information

• Chemical Name: N-BOC-3-MESYLOXYPIPERIDINE
• CAS No.: 129888-60-4
• Molecular Formula: C11H21NO5S
• Molecular Weight: 279.357
• Hs Code.: 2933399090
• Mol file: 129888-60-4.mol

Synonyms:N-Boc-3-mesyloxypiperidine;

Chemical Property of N-BOC-3-MESYLOXYPIPERIDINE

Chemical Property:

• Vapor Pressure: 7.69E-07mmHg at 25°C
• Refractive Index: 1.5
• Boiling Point: 407.2 °C at 760 mmHg
• PKA: -3.34±0.40(Predicted)
• Flash Point: 200.1 °C
• PSA: 81.29000
• Density: 1.22 g/cm³
• LogP: 2.38080
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Boc-3-Methanesulfonyloxy-piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-BOC-3-MESYLOXYPIPERIDINE

There total 7 articles about N-BOC-3-MESYLOXYPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butoxycarbonyl-3-piperidinol (85275-45-2) + methanesulfonyl chloride (124-63-0) → 1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine (129888-60-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield: 96.0%

N-tert-butoxycarbonyl-3-piperidinol (85275-45-2) + methanesulfonyl chloride (124-63-0) + triethylamine (121-44-8) → 1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine (129888-60-4)

Guidance literature:

In tetrahydrofuran; ethyl acetate;

Reference yield: 90.0%

N-tert-butoxycarbonyl-3-piperidinol (85275-45-2) + Methanesulfonic anhydride (7143-01-3) → 1-(tert-Butoxycarbonyl)-3-(methanesulfonyloxy)piperidine (129888-60-4)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; for 16h;

upstream raw materials:

N-tert-butoxycarbonyl-3-piperidinol

methanesulfonyl chloride

3-hydroxypiperazine

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₂H₂₅F₂NO₄

tert-butyl 3-(4-(3-(pyridin-4-yl)-1-trityI-1H-indazol-5-yl)-1H-pyrazoI-1-yl)piperidine-1-carboxylate

tert-butyl 3-(acetylsulfanyl)piperidine-1-carboxylate

tert-butyl 1,2,3,4-tetrahydro-1-pyridinecarboxylate

Refernces

• 1、 -. "PYRAZOLE DERIVATIVES AS H4 ANTAGONIST COMPOUNDS". Paragraph 37; 46; 47. . Retrieved 2020/05/21.
• 2、 Tong, Lexian,Song, Pinrao,Jiang, Kailong,Xu, Lei,Jin, Tingting,Wang, Peipei,Hu, Xiaobei,Fang, Sui,Gao, Anhui,Zhou, Yubo,Liu, Tao,Li, Jia,Hu, Yongzhou. "Discovery of (R)-5-((5-(1-methyl-1H-pyrazol-4-yl)-4-(methylamino)pyrimidin-2-yl)amino)-3-(piperidin-3-yloxy)picolinonitrile, a novel CHK1 inhibitor for hematologic malignancies". . p. 44 - 62. Retrieved 2019/04/17.