midodrine hydrochloride

Base Information

• Chemical Name: midodrine hydrochloride
• CAS No.: 133163-28-7
• Molecular Formula: C12H18N2O4
• Molecular Weight: 0
• Mol file: 133163-28-7.mol

Synonyms:Acetamide, 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]-, monohydrochloride, (R)- (9CI)

Chemical Property of midodrine hydrochloride

Chemical Property:

• Vapor Pressure: 4.64E-12mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 529.9°Cat760mmHg
• Flash Point: 274.3°C
• PSA: 97.30000
• Density: 1.204g/cm³
• LogP: 1.35270

Purity/Quality:

98% ^*data from raw suppliers

MIDODRINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of midodrine hydrochloride

There total 22 articles about midodrine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

midodrine (42794-76-3,133163-25-4,133267-39-7,97476-58-9) → midodrine hydrochloride (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

With hydrogenchloride; In ethanol; isopropyl alcohol;

Reference yield: 93.0%

2-Amino-N-[(S)-2-(2,5-dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-ethyl]-acetamide → <2S-(2α,3aα,4β,7β,7aα)>-2-Methoxy- (113775-57-8) + (S)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 ℃; for 0.0166667h;

DOI:10.1007/bf00807396

Reference yield: 93.0%

2-Amino-N-[(R)-2-(2,5-dimethoxy-phenyl)-2-((1R,2R,4S,6R,7R)-1,10,10-trimethyl-3-oxa-tricyclo[5.2.1.02,6]dec-4-yloxy)-ethyl]-acetamide → <2S-(2α,3aα,4β,7β,7aα)>-2-Methoxy- (113775-57-8) + (R)-2-Amino-N-<2-(2,5-dimethoxyphenyl)-2-hydroxyethyl>-acetamid-hydrochlorid (133163-28-7,3092-17-9,43218-56-0)

Guidance literature:

With hydrogenchloride; In methanol; diethyl ether; at 0 ℃; for 0.0166667h;

DOI:10.1007/bf00807396

upstream raw materials:

midodrine

2-azido-N-(β-hydroxy-2',5'-dimethoxyphenethyl)acetamide

BOC-glycine

desglymidodrine

Refernces

• 1、 -. "COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS". Page/Page column 45-49; 60. . Retrieved 2010/12/31.
• 2、 -. "AN IMPROVED PROCESS FOR THE SYNTHESIS OF (±) 2-AMINO-N-[2,(S,5-DIMETHOXYPHENYL)-2-HYDROXYETHYL] ACETAMIDE MONOHYDROCHLORIDE". Page 11-12. . Retrieved 2008/06/13.