2,3,4-TRIBROMOPHENOL

Base Information

• Chemical Name: 2,3,4-TRIBROMOPHENOL
• CAS No.: 138507-65-0
• Molecular Formula: C6H3Br3O
• Molecular Weight: 330.801
• Mol file: 138507-65-0.mol

Synonyms:2,3,4-TRIBROMOPHENOL

Chemical Property of 2,3,4-TRIBROMOPHENOL

Chemical Property:

• Melting Point: 95 °C
• Boiling Point: 302.5±37.0 °C(Predicted)
• PKA: 6.91±0.23(Predicted)
• PSA: 20.23000
• Density: 2.424±0.06 g/cm3(Predicted)
• LogP: 3.67970

Purity/Quality:

98% ^*data from raw suppliers

2,3,4-TRIBROMOPHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,3,4-Tribromophenol is a metabolite of polybrominated diphenyl ether and also functions as a potential biomaker for human exposure to polybrominated diphenyl ethers (PBDES).

Technology Process of 2,3,4-TRIBROMOPHENOL

There total 10 articles about 2,3,4-TRIBROMOPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.7%

2,3,4-tribromophenyl acetate (886748-36-3) → 2,3,4-tribromo-phenol (138507-65-0)

Guidance literature:

With potassium hydroxide; In methanol; for 24h; Heating;

DOI:10.1016/j.tet.2006.01.092

Reference yield: 45.0%

2,3,4-tribromoaniline (642-95-5) → 2,3,4-tribromo-phenol (138507-65-0)

Guidance literature:

2,3,4-tribromoaniline; With trifluoroacetic acid; sodium nitrite; at 0 ℃;

With sulfuric acid; sodium sulfate; for 0.833333h; Heating;

DOI:10.1021/es0107475

Reference yield:

N-bromoacetamide (79-15-2) + phenol (108-95-2,27073-41-2) → acetamide (60-35-5) + 2,3,4-tribromo-phenol (138507-65-0)

Guidance literature:

upstream raw materials:

3-Bromophenol

N-bromoacetamide

phenol

bromine

Downstream raw materials:

2,3,4-tribromo-anisole

2,2',3,4,4'5'-hexabromodiphenyl ether

2,3,4-tribromo-6-nitro-anisole

bromobenzene

Refernces

• 1、 -. "Preparation of non-hazardous brominating reagents". . . Retrieved 2008/06/13.
• 2、 Chen,Konstantinov,Chittim,Joyce,Bols,Bunce. "Synthesis of polybrominated diphenyl ethers and their capacity to induce CYP1A by the Ah receptor mediated pathway". . p. 3749 - 3756. Retrieved 2007/10/03.